Cachexia has only one meaning
Cachexia has only one meaning
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恶病质只有一种含义
DOI：
10.1007/s00109-007-0231-0
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
F. Luft
中科院分区：
文献类型：
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作者：
F. Luft
恶病质是指由于任何使人衰弱的慢性疾病而导致的身体和精神的活力和力量的普遍下降。恶病质的定义是体重减轻、肌肉萎缩、疲劳、虚弱和食欲不振。这些特征将恶病质与饥饿明显区分开来。恶病质可能是各种潜在疾病的征兆。面对恶病质的医生通常会考虑癌症、某些传染病(如结核病或艾滋病)、寄生虫病、自身免疫性疾病或慢性心力衰竭的可能性。恶病质会使患者身体虚弱到由于食欲不振、虚弱和贫血而无法动弹的状态。对标准治疗的反应很差[1]。以上这些听起来足够直截了当了。然而，在PubMed上，发表了大约4500篇关于恶病质的论文；有趣的是，这些论文中有1000篇是评论。这种关系引发了人们的怀疑，即人们对这个问题知之甚少。Weber等人[2]在这一期中介绍了一种新的临床肌肉萎缩的反向标记物，即血浆肌红蛋白浓度的测量。他们的报告立即令人不安，因为他们的论文标题以问号结尾，这意味着代表作者缺乏自信。然而，整个恶病质领域都充满了问号。
Cachexia means any general reduction in vitality and strength of body and mind resulting from any debilitating chronic disease. Cachexia is defined as loss of weight, muscle atrophy, fatigue, weakness, and loss of appetite in someone who is not actively trying to lose weight. These features markedly distinguish cachexia from starvation. Cachexia can be a sign of various underlying disorders. Physicians confronted with cachexia generally consider the possibility of cancer, certain infectious diseases such as tuberculosis or AIDS, parasitic diseases, autoimmune disorders, or chronic heart failure. Cachexia physically weakens patients to a state of immobility stemming from loss of appetite, asthenia, and anemia. The response to standard treatments is poor [1]. The above sounds straightforward enough. However, in PubMed, about 4,500 papers have been published on cachexia; interestingly,> 1,000 of these papers are reviews. Such a relationship raises suspicion that little is known about the subject. Weber et al.[2], in this issue, introduce a novel inverse marker of clinical muscle wasting, namely, the measurement of plasma myoglobin concentration. Their report is immediately disconcerting, as the title of their paper ends in a question mark, implying a lack of self-confidence on behalf of the authors. However, the entire cachexia field is riddled with question marks.