Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila
Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila
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DOI：
10.1101/gad.215426.113
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发表时间：
2013-04-15
影响因子：
10.5
通讯作者：
Kuroda, Mitzi I.
中科院分区：
文献类型：
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作者：
Alekseyenko, Artyom A.;Ellison, Christopher E.;Kuroda, Mitzi I.
剂量补偿是由于不同的男性（XY）和女性（XX）核型的进化而产生的。在黑腹果蝇中，MSL复合物使雄性X转录增加约两倍。X特异性靶向被认为是通过与染色质进入位点（CES）的序列依赖性结合，然后顺式扩散到活性基因而发生的。我们测试了这个模型，询问新进化的性染色体臂在果蝇米兰达获得剂量补偿。我们发现了新的CES产生的证据，其序列和间距与D相似。为建立剂量补偿扩散模型提供了有力的支持。
Dosage compensation has arisen in response to the evolution of distinct male (XY) and female (XX) karyotypes. In Drosophila melanogaster, the MSL complex increases male X transcription approximately twofold. X-specific targeting is thought to occur through sequence-dependent binding to chromatin entry sites (CESs), followed by spreading in cis to active genes. We tested this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage compensation. We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation.