Rho-GTPase-regulated vesicle trafficking in plant cell polarity
Rho-GTPase-regulated vesicle trafficking in plant cell polarity
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DOI：
10.1042/bst20130269
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发表时间：
2014-02-01
影响因子：
3.9
通讯作者：
Friml, Juri
中科院分区：
文献类型：
--
作者：
Chen, Xu;Friml, Juri
ROPs（Rho of plants）是一类植物特异性Rho样小GTP酶家族，作为一种重要的分子开关，控制细胞骨架的形成、细胞极化、胞质分裂、细胞分化和囊泡运输等多种细胞过程。虽然植物中囊泡运输和细胞极性的机制已经单独得到很好的解决，但ROP如何协调这些过程仍然很不清楚。最近的进展已经取得了理解的协调ROP信号和PIN（PINFORMED）转运蛋白的植物激素生长素在根和叶铺面细胞。PIN转运蛋白不断穿梭于内体区室和极性质膜结构域之间，因此细胞之间PIN依赖性生长素转运的调节是ROP调节的囊泡运输的主要发育输出。本文着重介绍了这些细胞机制，特别是基于ROP的囊泡运输和植物细胞极性的整合。
ROPs (Rho of plants) belong to a large family of plant-specific Rho-like small GTPases that function as essential molecular switches to control diverse cellular processes including cytoskeleton organization, cell polarization, cytokinesis, cell differentiation and vesicle trafficking. Although the machineries of vesicle trafficking and cell polarity in plants have been individually well addressed, how ROPs co-ordinate those processes is still largely unclear. Recent progress has been made towards an understanding of the coordination of ROP signalling and trafficking of PIN (PINFORMED) transporters for the plant hormone auxin in both root and leaf pavement cells. PIN transporters constantly shuttle between the endosomal compartments and the polar plasma membrane domains, therefore the modulation of PIN-dependent auxin transport between cells is a main developmental output of ROP-regulated vesicle trafficking. The present review focuses on these cellular mechanisms, especially the integration of ROP-based vesicle trafficking and plant cell polarity.