Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases.
Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases.
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靶向衰老和衰老相关心血管疾病中的自噬
DOI：
10.1016/j.tips.2018.10.005
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发表时间：
2018-12
影响因子：
13.8
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Ren J;Zhang Y
衰老是一个不可逆的生物学过程，是癌症、肺部疾病、神经退行性疾病和心血管疾病等慢性疾病的独立危险因素。特别是，高发病率和死亡率已与心血管老化，虽然有效的临床治疗措施是次优的不断上升的老龄化人口。最近的证据表明，异常的聚集体清除和蛋白质质量控制机制-自噬过程在缩短寿命、损害健康寿命、衰老相关心血管疾病的发生和发展中具有独特的作用。自噬降解并去除长寿或受损的细胞器和蛋白质，其功能随着晚期衰老而下降。使用雷帕霉素、白藜芦醇、烟酰胺衍生物、二甲双胍、尿石素A和亚精胺诱导自噬延缓衰老、延长寿命并改善衰老中的心血管功能。考虑到人类寿命的不断延长和人口老龄化以及随着年龄的增加而引起的心血管疾病的患病率，理解自噬和细胞器选择性自噬的贡献和潜在机制（例如，线粒体自噬）在调节寿命、健康寿命和心血管衰老中的作用。在这里，我们将剖析衰老中自噬失败的作用机制，并讨论使用药理学药物靶向自噬的潜在原理，作为对抗生物和心血管衰老的新途径。
Aging, an irreversible biological process, serves as an independent risk factor for chronic disease including cancer, pulmonary, neurodegenerative and cardiovascular diseases. In particular, high morbidity and mortality has been associated with cardiovascular aging although effective clinical therapeutic remedy is suboptimal for the ever-rising aging population. Recent evidence suggests a unique role for aberrant aggregate clearance and protein quality control machinery - the process of autophagy in shortened lifespan, compromised healthspan, onset and development of aging-associated cardiovascular diseases. Autophagy degrades and removes long-lived or damaged cellular organelles and proteins, the functions of which decline with advanced aging. Induction of autophagy using rapamycin, resveratrol, nicotinamide derivatives, metformin, urolithin A and spermidine delays aging, prolongs lifespan and improves cardiovascular function in aging. Given the ever-rising human lifespan and aging population as well as the prevalence of cardiovascular disease provoked with increased age, it is pertinent to understand the contribution and underlying mechanisms for autophagy and organelle-selective autophagy (e.g., mitophagy) in the regulation of lifespan, healthspan and cardiovascular aging. Here we will dissect the mechanism of action for autophagy failure in aging and discuss the potential rationale of targeting autophagy using pharmacological agents as new avenues in the combat of biological and cardiovascular aging.
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影响因子：
7.8
作者：
Dai DF;Karunadharma PP;Chiao YA;Basisty N;Crispin D;Hsieh EJ;Chen T;Gu H;Djukovic D;Raftery D;Beyer RP;MacCoss MJ;Rabinovitch PS
通讯作者：
Rabinovitch PS
影响因子：
--
作者：
Chao J;Guo Y;Li P;Chao L
通讯作者：
Chao L
DOI：
10.18632/aging.100881
发表时间：
2016-02
期刊：
Aging
影响因子：
--
作者：
Chiao YA;Kolwicz SC;Basisty N;Gagnidze A;Zhang J;Gu H;Djukovic D;Beyer RP;Raftery D;MacCoss M;Tian R;Rabinovitch PS
通讯作者：
Rabinovitch PS
影响因子：
7.8
作者：
Guo Y;Li P;Gao L;Zhang J;Yang Z;Bledsoe G;Chang E;Chao L;Chao J
通讯作者：
Chao J
DOI：
10.1038/nrcardio.2017.35
发表时间：
2017-07
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Delbridge LMD;Mellor KM;Taylor DJ;Gottlieb RA
通讯作者：
Gottlieb RA