Anabolic steroids detected in bodybuilding dietary supplements - a significant risk to public health
Anabolic steroids detected in bodybuilding dietary supplements - a significant risk to public health
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DOI：
10.1002/dta.1728
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发表时间：
2015-07-01
影响因子：
2.9
通讯作者：
Walker, C. J.
中科院分区：
文献类型：
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作者：
Abbate, V.;Kicman, A. T.;Walker, C. J.
对在英国健身器材店销售的24种怀疑含有合成类固醇的产品进行了定性和半定量分析，方法包括全扫描气相色谱-质谱仪(GC-MS)、准确质谱联用质谱仪(LC-MS)、高效液相二极管阵列检测器(HPLC-DAD)、紫外-可见光谱(UV-Vis)和核磁共振(核磁共振)谱。此外，X射线结晶学能够在没有参照标准的情况下鉴定其中一种化合物。在检测的24种产品中，23种含有类固醇，包括已知的合成代谢药物；其中16种含有与包装上显示的不同的类固醇，还有一种产品根本不含类固醇。总体而言，确定了13种不同的类固醇；其中12种在英国受到1971年《滥用药物法》的管制。根据其化学结构和含量，其中几种产品含有可被认为具有相当大药理活性的类固醇。这可能会在不知不觉中使用户面临严重的健康风险，这对天真的用户来说尤其令人担忧。版权所有(C)2014 John Wiley&Sons，Ltd.
Twenty-four products suspected of containing anabolic steroids and sold in fitness equipment shops in the United Kingdom (UK) were analyzed for their qualitative and semi-quantitative content using full scan gas chromatography-mass spectrometry (GC-MS), accurate mass liquid chromatography-mass spectrometry (LC-MS), high pressure liquid chromatography with diode array detection (HPLC-DAD), UV-Vis, and nuclear magnetic resonance (NMR) spectroscopy. In addition, X-ray crystallography enabled the identification of one of the compounds, where reference standard was not available. Of the 24 products tested, 23 contained steroids including known anabolic agents; 16 of these contained steroids that were different to those indicated on the packaging and one product contained no steroid at all. Overall, 13 different steroids were identified; 12 of these are controlled in the UK under the Misuse of Drugs Act 1971. Several of the products contained steroids that may be considered to have considerable pharmacological activity, based on their chemical structures and the amounts present. This could unwittingly expose users to a significant risk to their health, which is of particular concern for naive users. Copyright (c) 2014 John Wiley & Sons, Ltd.