Associations between mammographic density and body composition in Hispanic and non-Hispanic white women by menopause status
Associations between mammographic density and body composition in Hispanic and non-Hispanic white women by menopause status
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DOI：
10.1097/gme.0b013e3181405b8a
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发表时间：
2008-03-01
影响因子：
2.7
通讯作者：
Chen, Zhao
中科院分区：
文献类型：
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作者：
Caire-Juvera, Graciela;Arendell, Leslie A.;Chen, Zhao
目的：为了评估协会的身体成分，包括瘦肉和脂肪质量的百分比，与乳腺摄影密度和乳腺摄影密集区的百分比在绝经前和绝经后的西班牙裔和非西班牙裔白色women.Design：在这个横断面研究中，共238名妇女年龄在41至50岁或56至70岁，从当地的乳腺摄影诊所和社区卫生中心招募。绝经后状态定义为过去12个日历月内没有任何月经周期或促卵泡激素水平在22至138 mIU/mL之间。参与者最近的乳房X线照片用于乳房X线密度分析。采用双能X线吸收法测量身体成分。乳腺摄影密度或乳腺摄影致密区和身体成分的百分比之间的关联进行了分析，使用logistic regression.Results：乳腺摄影致密区在西班牙裔和非西班牙裔白色妇女相似。乳腺摄影密度的百分比在绝经前的种族不同（P = 0.023），但在绝经后的妇女。身体成分，高瘦体重和低脂肪体重，与较高的乳腺摄影密度百分比相关（P < 0.05）。有趣的是，在绝经前女性中，较高的全身脂肪量百分比和较低的全身瘦体重百分比与较大的乳腺密度区域相关，但在绝经后女性中与较低的乳腺密度区域相关。这些身体成分和乳房X线摄影密度测量之间的关系没有显着影响的因素，如年龄，种族，和bodyweight.Conclusions：身体成分是高度相关的乳房X线摄影密度，并应检查作为一个可能的混杂因素，在研究中，涉及乳房X线摄影密度测量和乳腺癌的风险。
Objective: To evaluate the associations of body composition, including percentage of lean and fat mass, with the percentage of mammographic density and mammographic dense area among pre- and postmenopausal Hispanic and non-Hispanic white women.Design: In this cross-sectional study, a total of 238 women aged 41 to 50 or 56 to 70 years were recruited from local mammography clinics and community health centers. Postmenopausal status was defined as an absence of any menstrual cycle within the past 12 calendar months or having a follicle-stimulating hormone level between 22 and 138 mIU/mL. The participants' most recent mammograms were used for the mammographic density analysis. Body composition was measured by dual-energy x-ray absorptiometry. The associations between the percentage of mammographic density or mammographic dense area and body composition components were analyzed using logistic regression.Results: Mammographic dense areas were similar in Hispanic and non-Hispanic white women. The percentage of mammographic density varied by ethnicity in premenopausal (P = 0.023), but not in postmenopausal women. Body composition, both higher lean mass and lower fat mass, was associated with a higher percentage of mammographic density (P < 0.05). Interestingly, a higher percentage of total body fat mass and a lower percentage of total body lean mass were correlated with larger breast dense areas in premenopausal women but with lower breast dense areas in postmenopausal women. These relationships between body composition and mammographic density measurements were not significantly affected by factors such as age, ethnicity, and body weight.Conclusions: Body composition is highly correlated with mammographic density and should be examined as a possible confounding factor in studies involving mammographic density measurements and breast cancer risk.