The retinal vasculature in macular degeneration.
The retinal vasculature in macular degeneration.
复制标题
黄斑变性中的视网膜血管系统。
DOI：
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发表时间：
1966
期刊：
影响因子：
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通讯作者：
M. Feldstein
中科院分区：
文献类型：
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作者：
A. Kornzweig;I. Eliasoph;M. Feldstein
清楚地了解黄斑变性的发病机制将是我们对病理学知识的重大补充，更重要的是，将为我们提供合理治疗的可能性。过去关于这一课题的工作指出，玻璃板的变化和脉络膜毛细血管的变化可能是导致视网膜破裂的原因。1-4视网膜常规组织学切片未能显示与此疾病过程有关的视网膜血管系统的任何重大变化。在过去的几年里，我们的老年人口有了巨大的增长，统计研究表明，65岁以后的黄斑变性在某种程度上涉及到几乎三分之一的被研究眼睛。5在生命的早期，基于遗传性退行性疾病的黄斑变性是相对罕见的。黄斑确实参与了这种情况的全身性视网膜病变。
A clear understanding of the pathogenesis of macular degeneration would be a major addition to our knowledge of pathology, and more important, would give us the possibility of a rational therapy. Past work on this subject has pointed to changes in the lamina vitrea and changes in the choriocapillaris as possible origins of the breakdown that occurs.1-4Routine histological sections of the retina have failed to show any significant alteration in the retinal vascular system in relation to this disease process. Our population of aged persons has grown tremendously in the last few years and statistical studies have shown macular degeneration after age 65 to involve to some degree almost one third of all eyes studied.5Macular degeneration as seen in the early years of life on the basis of heredodegenerative disease is relatively a rarity. The macula does become involved in the generalized retinopathy of such conditions