Serum estrogen metabolites and systolic blood pressure among middle-aged and older women and men.
Serum estrogen metabolites and systolic blood pressure among middle-aged and older women and men.
复制标题
中老年女性和男性血清雌激素代谢物和收缩压。
DOI：
10.1038/ajh.2009.155
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发表时间：
2009
影响因子：
3.2
通讯作者：
Cacioppo,JohnT
中科院分区：
文献类型：
--
作者：
Masi,ChristopherM;Hawkley,LouiseC;Xu,Xia;Veenstra,TimothyD;Cacioppo,JohnT
背景高血压在年轻男性和60岁以上女性中更为常见，这表明内源性雌激素和收缩压（SBP）之间可能存在联系。我们测试了血清17β-雌二醇（E2）或其任何代谢物是否与中老年人群的收缩压有关。方法采用横断面研究设计，我们检查了居住在伊利诺伊州库克县的98名成年人的人口样本数据。年龄在55 - 69岁之间，身体质量指数（BMI）在19.8 - 50.6 kg/m2之间。用质谱法分析血清中17种β- e2和14种雌激素代谢物（EMs）。收缩压是用一种测压装置测量的，该装置记录桡动脉的脉搏波。通过问卷调查获得人口统计和健康史信息。结果单因素分析显示，女性收缩压与自然对数（ln） 16α-羟孕酮（OHE1） （r= - 0.360，P< 0.05）和ln 16-酮雌二醇（r= - 0.360，P< 0.05）呈负相关，而男性无相关。收缩压与17β- e2在两性中均无显著相关性。在调整年龄、种族、民族、BMI和心血管药物使用的多因素分析中，ln 16α-羟酮（16α-OHE1） （B= - 5.3, s.e = 2.1，P< 0.05）和ln 16-酮e2 （B= - 4.7, s.e = 1.9，P< 0.05）继续与绝经后妇女的收缩压呈负相关。结论血清16α- ohe1或16-酮e2可能对绝经后女性血管健康有重要作用，而对同龄男性无重要作用。美国高血压杂志2009；22:1148-1153©2009美国高血压杂志
BackgroundHypertension is more common among men at younger ages and among women after age 60, suggesting a possible link between endogenous estrogens and systolic blood pressure (SBP). We tested whether serum 17β-estradiol (E2) or any of its metabolites were associated with SBP among middle-aged and older adults.MethodsUsing a cross-sectional study design, we examined data from a population-based sample of 98 adults living in Cook County, Illinois. Age ranged between 55 and 69 years and body mass index (BMI) ranged between 19.8 and 50.6 kg/m2. Serum was analyzed for 17β-E2and 14 estrogen metabolites (EMs) using mass spectrometry. SBP was measured using a tonometric device that records a pulse wave at the radial artery. Demographic and health history information were obtained via questionnaires.ResultsUnivariate analysis revealed an inverse relationship between SBP and both natural log (ln) 16α-hydroxyestrone (OHE1) (r= −0.360,P< 0.05) and ln 16-ketoestradiol (ketoE2) (r= −0.360,P< 0.05) among women but not men. No significant correlations were found between SBP and 17β-E2in either sex. In multivariate analysis which adjusted for age, race, ethnicity, BMI, and use of cardiovascular medications, ln 16α-hydroxyestrone (16α-OHE1) (B= −5.3, s.e. = 2.1,P< 0.05) and ln 16-ketoE2(B= −4.7, s.e. = 1.9,P< 0.05) continued to be negatively associated with SBP among postmenopausal women.ConclusionsThese data suggest that serum 16α-OHE1or 16-ketoE2may be important for vascular health among postmenopausal women but not among similarly aged men.American Journal of Hypertension2009;22:1148–1153 © 2009 American Journal of Hypertension, Ltd.