Sensitization of depressive-like behavior during repeated maternal separation is associated with more-rapid increase in core body temperature and reduced plasma cortisol levels.
Sensitization of depressive-like behavior during repeated maternal separation is associated with more-rapid increase in core body temperature and reduced plasma cortisol levels.
复制标题
反复与母亲分离期间抑郁样行为的敏感性与核心体温的更快升高和血浆皮质醇水平的降低有关。
DOI：
10.1016/j.physbeh.2011.10.026
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发表时间：
2012
影响因子：
2.9
通讯作者：
Hennessy,MichaelB
中科院分区：
文献类型：
--
作者：
Yusko,Brittany;Hawk,Kiel;Schiml,PatriciaA;Deak,Terrence;Hennessy,MichaelB
婴儿豚鼠对母亲分离表现出两个阶段的反应：最初的主动阶段，以发声为特征；第二个被动阶段，以抑郁样行为为特征（驼背姿势，长时间闭眼，广泛的毛囊勃起），这似乎是由促炎活动介导的。最近我们发现，在反复分离期间，幼崽表现出一种增强的（即敏感的）抑郁样行为反应。此外，与第一次分离相比，在第二次分离开始时，核心体温更高，这表明第二天对分离的应激性发热反应更快，尽管不能排除在第二次分离之前体温已经升高的可能性。因此，本研究检查温度之前，和期间，每天两次分离。我们还检查了在第二次分离后3天进行的第三次分离的温度反应，并评估了反复分离对血浆皮质醇水平的影响。岩心温度在分离前没有变化，但在第二次和第三次分离中都表现出比第一次分离更快的上升和下降。温度反应与运动活动的变化无关。在第二次和第三次分离期间，类似抑郁的行为更严重。第一次分离的幼鼠在分离结束时比第三次分离的同龄幼鼠表现出更大的血浆皮质醇反应。总之，结果表明，在连续数天的反复分离中，抑郁样行为的敏感性伴随着更快速的发热反应，这可能与糖皮质激素抑制的减少有关。
Infant guinea pigs exhibit a 2-stage response to maternal separation: an initial active stage, characterized by vocalizing, and a second passive stage marked by depressive-like behavior (hunched posture, prolonged eye-closure, extensive piloerection) that appears to be mediated by proinflammatory activity. Recently we found that pups showed an enhanced (i.e., sensitized) depressive-like behavioral response during repeated separation. Further, core body temperature was higher during the beginning of a second separation compared to the first, suggesting a more-rapid stress-induced febrile response to separation the second day, though the possibility that temperature was already elevated prior to the second separation could not be ruled out. Therefore, the present study examined temperature prior to, and during, 2 daily separations. We also examined the temperature response to a third separation conducted 3days after the second, and assessed the effect of repeated separation on plasma cortisol levels. Core temperature did not differ just prior to the separations, but showed a more-rapid increase and then decline during both a second and third separation than during a first. Temperature responses were not associated with changes in motor activity. Depressive-like behavior was greater during the second and third separations. Pups separated a first time showed a larger plasma cortisol response at the conclusion of separation than did animals of the same age separated a third time. In all, the results indicate that the sensitization of depressive-like behavior during repeated separations over several days is accompanied by a more-rapid febrile response that may be related to a reduction of glucocorticoid suppression.