Rat cardiac muscle single cell automaticity responses to alpha- and beta-adrenergic agonists and antagonists.
Rat cardiac muscle single cell automaticity responses to alpha- and beta-adrenergic agonists and antagonists.
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大鼠心肌单细胞对α-和β-肾上腺素能激动剂和拮抗剂的自动反应。
DOI：
10.1161/01.res.51.4.532
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发表时间：
1982
影响因子：
20.1
通讯作者：
Becker,P
中科院分区：
文献类型：
--
作者：
Hermsmeyer,K;Mason,R;Griffen,SH;Becker,P
从新生大鼠心室肌分离的心肌细胞具有α-和β-肾上腺素能的正变时性反应，对应用的肾上腺素能药物的敏感性比完整的新生心脏高100倍以上。这些高度敏感的分离的单细胞和小细胞群也揭示了α-肾上腺素能拮抗剂酚妥拉明和β-肾上腺素能拮抗剂普萘洛尔的部分激动剂活性。高敏感性最可能的解释是缺乏脱敏过程，这可能涉及脱敏物质和受体的变化。这些实验表明，所有肾上腺素能拮抗剂可能显示部分激动剂活性。
Isolated cardiac muscle cells from neonatal rat ventricular myocardium have both alpha- and beta-adrenergic, positive chronotropic responses, with sensitivity to applied adrenergic agents more than 100 times greater than the intact neonatal heart. These highly sensitive isolated single cells and small groups of cells also reveal partial agonist activity of the alpha-adrenergic antagonist, phentolamine, and the beta-adrenergic antagonist, propranolol. The most likely explanation for the high sensitivity is the lack of a desensitization process that could involve both a desensitization substance and changes in receptors. These experiments suggest that all adrenergic antagonists could possibly show partial agonist activity.