Precision of Flow Sensing by Self-Communicating Cells
Precision of Flow Sensing by Self-Communicating Cells
复制标题
自通信单元的流量传感精度
DOI：
10.1103/physrevlett.124.168101
复制
发表时间：
2020
影响因子：
8.6
通讯作者：
Mugler, Andrew
中科院分区：
文献类型：
--
作者：
Fancher, Sean;Vennettilli, Michael;Hilgert, Nicholas;Mugler, Andrew
转移性癌细胞通过自我交流检测淋巴流向：它们分泌并检测一种化学物质，由于流动，该化学物质各向异性地返回细胞表面。分泌速率低，意味着检测噪声可能起重要作用，但尚未探索这种机制的感官精度。在这里，我们推导出两种无处不在的检测方法的流量传感的精度：吸收与可逆结合到表面受体。我们发现，由于吸收扭曲了细胞旨在检测的信号，因此结合更加精确。与实验相比，我们的结果表明，癌细胞的操作非常接近物理检测极限。我们预测细胞应该可逆地结合化学物质，而不是吸收它，这一预测得到了配体-受体对的内吞作用数据的支持。
Metastatic cancer cells detect the direction of lymphatic flow by self-communication: they secrete and detect a chemical which, due to the flow, returns to the cell surface anisotropically. The secretion rate is low, meaning detection noise may play an important role, but the sensory precision of this mechanism has not been explored. Here we derive the precision of flow sensing for two ubiquitous detection methods: absorption vs reversible binding to surface receptors. We find that binding is more precise due to the fact that absorption distorts the signal that the cell aims to detect. Comparing to experiments, our results suggest that the cancer cells operate remarkably close to the physical detection limit. Our prediction that cells should bind the chemical reversibly, not absorb it, is supported by endocytosis data for this ligand-receptor pair.