Stimulation of thymidine incorporation in isolated rat intestinal mucosal cells by feeding an ethanol-containing liquid diet.
Stimulation of thymidine incorporation in isolated rat intestinal mucosal cells by feeding an ethanol-containing liquid diet.
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通过喂食含乙醇的流质饮食刺激离体大鼠肠粘膜细胞中胸苷的掺入。
DOI：
10.1159/000198711
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发表时间：
1982
期刊：
影响因子：
3.2
通讯作者：
B. Kommerell
中科院分区：
文献类型：
--
作者：
H. Seitz;P. Czygan;B. Kommerell
研究了慢性乙醇给药对大鼠离体肠细胞~ 3 H-胸苷掺入DNA的影响。慢性乙醇消耗显著增加肠粘膜细胞的DNA合成。这种DNA合成的增强作为细胞再生的量度是否是由于乙醇通过组织损伤的局部作用、乙醇对参与DNA代谢的酶活性的直接刺激作用或肠细胞群中的变化（乙醇使肠细胞群向未成熟的隐窝细胞转变）所致尚不清楚。
The effect of chronic ethanol administration on the incorporation of 3H-thymidine into DNA of isolated intestinal cells in the rat was investigated. Chronic ethanol consumption increased significantly DNA synthesis in intestinal mucosal cells. Whether this enhancement of DNA synthesis as a measure for cellular regeneration is due to the local effect of ethanol via tissue injury, to a direct stimulatory effect of ethanol on enzyme activities involved in DNA metabolism or to a change in the intestinal cell population with a shift to immature crypt cells by ethanol is not known.