Regulation of Osteoblast Differentiation by Runx2
Regulation of Osteoblast Differentiation by Runx2
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DOI：
10.1007/978-1-4419-1050-9_5
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发表时间：
2010-01-01
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影响因子：
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通讯作者：
Komori, Toshihisa
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文献类型：
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作者：
Komori, Toshihisa
Runx2蛋白首先在前成骨细胞中检测到，并且在未成熟成骨细胞中表达上调，但在成熟成骨细胞中表达下调。Runx2是决定成骨细胞谱系所需的第一个转录因子，而Sp7和经典Wnt信号传导进一步将间充质细胞的命运导向成骨细胞，阻止其分化为软骨细胞。Runx2诱导多能间充质细胞分化为未成熟成骨细胞，指导未成熟骨的形成，但Runx2抑制成骨细胞成熟和成熟骨形成。正常情况下，成骨细胞中Runx2的蛋白水平在骨发育过程中降低，成骨细胞获得成熟骨形成所需的成熟表型。此外，Runx2在成骨细胞分化的早期阶段触发主要骨基质基因的表达，但是Runx2对于在成熟成骨细胞中维持这些基因表达不是必需的。
Runx2 protein is first detected in preosteoblasts, and the expression is upregulated in immature osteoblasts, but downregulated in mature osteoblasts. Runx2 is the first transcription factor required for determination of the osteoblast lineage, while Sp7 and canonical Wnt-signaling further direct the fate of mesenchymal cells to osteoblasts, blocking their differentiation into chondrocytes. Runx2 induces the differentiation of multipotent mesenchymal cells into immature osteoblasts, directing the formation of immature bone, but Runx2 inhibits osteoblast maturation and mature bone formation. Normally, the protein level of Runx2 in osteoblasts reduces during bone development, and osteoblasts acquire mature phenotypes, which are required for mature bone formation. Furthermore, Runx2 triggers the expression of major bone matrix genes during the early stages of osteoblast differentiation, but Runx2 is not essential for the maintenance of these gene expressions in mature osteoblasts.