The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine ('Ecstasy') in healthy volunteers
The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine ('Ecstasy') in healthy volunteers
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DOI：
10.1177/026988110001400313
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发表时间：
2000-09-01
影响因子：
4.1
通讯作者：
Vollenweider, FX
中科院分区：
文献类型：
--
作者：
Liechti, ME;Vollenweider, FX
MDMA(3，4-亚甲基二氧基甲基苯丙胺)或“摇头丸”是一种广泛使用的娱乐药物，会产生情绪高涨的状态，但也会对心血管和植物产生副作用。在动物体内，MDMA会释放5-羟色胺，并在较小程度上释放多巴胺和去甲肾上腺素。5-羟色胺的释放可以被5-羟色胺摄取抑制剂如西酞普兰所阻断。目前尚不清楚这一机制在多大程度上也是导致MDMA在人类身上出现的生理副作用的原因。我们观察了西酞普兰(40 mg，i.v)对其的影响。MDMA(1.5 mg/kg P.O.)对植物和心血管的影响在一项针对16名健康志愿者的双盲安慰剂对照研究中。MDMA适度增加血压和心率，轻微升高体温，并产生广泛的急性和短期副作用。除体温外，西酞普兰可减少MDMA引起的所有这些生理变化。这些发现表明，MDMA对人体的生理作用部分是由于MDMA与5-羟色胺载体的相互作用以及随后5-羟色胺的释放。
MDMA (3,4-methylenedioxymethamphetamine) or 'Ecstasy' is a widely used recreational drug that produces a state of heightened mood but also cardiovascular and vegetative side-effects. In animals, MDMA releases serotonin and, to a lesser extent, dopamine and norepinephrine. The release of serotonin can be blocked by serotonin uptake inhibitors such as citalopram. It is unknown to what extent this mechanism is also responsible for the physiological side-effects of MDMA seen in humans. We investigated the effect of citalopram pretreatment (40 mg i.v.) on vegetative and cardiovascular effects of MDMA (1.5 mg/kg p.o.) in a double-blind placebo-controlled study in 16 healthy volunteers. MDMA moderately increased blood pressure and heart rate, slightly elevated body temperature and produced a broad range of acute and shortterm side-effects. Citalopram reduced all these MDMA-induced physiological changes except for body temperature. These findings suggest that physiological effects of MDMA in humans are partially due to an interaction of MDMA with the serotonin carrier and a subsequent release of serotonin.