A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei.
A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei.
复制标题
针对环子孢子蛋白的 T 细胞克隆，可保护小鼠免受约氏疟原虫和伯氏疟原虫的侵害。
作者：
Walter R. Weiss;J. A. Berzofsky;Richard A. Houghten;M. Sedegah;M. Hollindale;S. L. Hoffman
克隆 B 是通过约氏疟原虫子孢子免疫诱导的细胞毒性 T 细胞克隆，其识别约氏疟原虫和伯氏疟原虫环子孢子蛋白上的表位。它是 CD8，使用 V beta 8.1 TCR，并且受到 Kd 限制。当过继转移时，它可以保护小鼠免受两种疟疾子孢子的感染，这种保护依赖于 IFN-γ。克隆 B 细胞比之前描述的针对疟疾的鼠 T 细胞克隆具有更广泛的反应性和保护性。克隆 B 可能是针对自然界中各种变异寄生虫的免疫保护的重要模型。
Clone B is a cytotoxic T cell clone induced by immunization with Plasmodium yoelii sporozoites which recognizes an epitope on both the P. yoelii and Plasmodium berghei circumsporozoite proteins. It is CD8, uses the V beta 8.1 TCR, and is Kd restricted. When adoptively transferred, it protects mice against infection by both species of malaria sporozoites, and this protection is dependent on IFN-gamma. Clone B cells are more broadly reactive and protective than previously described murine T cell clones against malaria. Clone B may be an important model for immune protection against the spectrum of variant parasites in nature.