Optical Coherence Tomography Angiography to Quantify Choroidal Neovascularization in Response to Aflibercept
Optical Coherence Tomography Angiography to Quantify Choroidal Neovascularization in Response to Aflibercept
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DOI：
10.1159/000487611
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发表时间：
2018-05
期刊：
影响因子：
2.6
通讯作者：
Jun Takeuchi;K. Kataoka;Yasuki Ito;K. Takayama;T. Yasuma;Hiroki Kaneko;H. Terasaki
中科院分区：
文献类型：
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作者：
Jun Takeuchi;K. Kataoka;Yasuki Ito;K. Takayama;T. Yasuma;Hiroki Kaneko;H. Terasaki
目的：利用光学相干断层扫描血管造影（OCTA）研究抗血管内皮生长因子（VEGF）治疗期间脉络膜新生血管（CNV）的微血管变化。方法：我们回顾性收集了患有典型年龄相关性黄斑变性的连续未接受治疗的眼睛的数据，这些眼睛最初接受了 3 次阿柏西普注射。 OCTA 在基线以及随访 1、2 和 4 个月时进行。使用开源软件分析 CNV 图像以评估血管面积和连接密度。结果：纳入 15 名患者的 15 只眼睛。基线时的平均血管面积为 0.50 ± 0.33 mm2；第 1、2 和 4 个月时，血管面积相对于基线的变化率分别为 66.6 ± 38.8%、80.5 ± 25.5% 和 94.0 ± 29.3%。血管面积在 1 个月时较基线显着减少 (p = 0.0015)，但在 4 个月时较 1 个月时显着增加 (p = 0.011)。平均连接密度也从基线时的 4.70 ± 1.30/mm 显着降低至 1 个月时的 3.82 ± 1.06/mm (p = 0.00084)。然而，连接密度在第 2 个月和第 4 个月时并没有继续下降。结论：OCTA 定量显示，尽管第一次注射后 CNV 有所收缩，但重复注射阿柏西普后 CNV 出现反弹。
Purpose: To investigate the microvascular changes in choroidal neovascularization (CNV) using optical coherence tomography angiography (OCTA) during anti-vascular endothelial growth factor (VEGF) therapies. Methods: We retrospectively collected data on consecutive treatment-naïve eyes with typical age-related macular degeneration that initially received 3 aflibercept injections. OCTA was performed at baseline and at 1, 2, and 4 months of follow-up. The CNV images were analyzed using open-source software to assess vessel area and junction density. Results: Fifteen eyes of 15 patients were included. The mean vessel area at baseline was 0.50 ± 0.33 mm2; at 1, 2, and 4 months, the ratios of change in vessel area from baseline were 66.6 ± 38.8%, 80.5 ± 25.5%, and 94.0 ± 29.3%, respectively. The vessel area was significantly reduced at 1 month from that at baseline (p = 0.0015) but significantly increased at 4 months from that at 1 month (p = 0.011). The mean junction density was also significantly reduced from 4.70 ± 1.30/mm at baseline to 3.82 ± 1.06/mm at 1 month (p = 0.00084). However, junction density did not continue to decrease at 2 and 4 months. Conclusion: OCTA quantification revealed that CNV rebounded after repeat aflibercept injections despite shrinking in response to the first injection.