Long-term Influences of Prenatal Maternal Depressive Symptoms on the Amygdala-Prefrontal Circuitry of the Offspring From Birth to Early Childhood
Long-term Influences of Prenatal Maternal Depressive Symptoms on the Amygdala-Prefrontal Circuitry of the Offspring From Birth to Early Childhood
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DOI：
10.1016/j.bpsc.2019.05.006
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发表时间：
2019-11-01
影响因子：
5.9
通讯作者：
Qiu, Anqi
中科院分区：
文献类型：
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作者：
Lee, Annie;Poh, Joann S.;Qiu, Anqi
背景：产前母亲抑郁可能对杏仁核皮质发育有长期影响。本研究探讨了产前母亲抑郁症状的杏仁核皮质结构协方差的后代从出生到幼儿期，来自纵向birth cohort.METHODS：结构磁共振成像进行，以获得杏仁核体积和皮质厚度在每个时间点的协会。在怀孕26周时使用爱丁堡产后抑郁量表测量产前产妇的抑郁症状。回归分析被用来检验爱丁堡产后抑郁量表对杏仁核体积和皮质厚度在出生时（n = 167）和4.5岁时（n = 199）之间的结构耦合的影响。母亲产前抑郁症状高的女孩在出生时杏仁核体积和杏仁核厚度之间表现出正耦合（β = 0.617，p = 0.001），但在4.5岁时杏仁核体积和下额叶厚度之间显示出负耦合（β = -0.369，p = 0.008）。没有发现发现在男孩在任何时间point.CONCLUSIONS：杏仁核前额叶回路的发展是容易受到抑郁症相关的环境因素。这种脆弱性可能取决于性别。
BACKGROUND: Prenatal maternal depression may have long-term impacts on amygdala-cortical development. This study explored associations of prenatal maternal depressive symptoms on the amygdala-cortical structural covariance of the offspring from birth to early childhood, derived from a longitudinal birth cohort.METHODS: Structural magnetic resonance imaging was performed to obtain the amygdala volume and cortical thickness at each time point. Prenatal maternal depressive symptoms were measured using the Edinburgh Postnatal Depression Scale at 26 weeks of pregnancy. Regression analysis was used to examine the effects of the Edinburgh Postnatal Depression Scale on a structural coupling between the amygdala volume and cortical thickness at birth (n = 167) and 4.5 years of age (n = 199).RESULTS: Girls whose mothers had high prenatal maternal depressive symptoms showed a positive coupling between the amygdala volume and insula thickness at birth (beta = .617, p = .001) but showed a negative coupling between the amygdala volume and inferior frontal thickness at 4.5 years of age (beta = -.369, p = .008). No findings were revealed in boys at any time point.CONCLUSIONS: The development of the amygdala-prefrontal circuitry is vulnerable to environmental factors related to depression. Such a vulnerability might be sex dependent.