DE-NOVO PROTEIN DESIGN - FROM MOLTEN GLOBULES TO NATIVE-LIKE STATES
DE-NOVO PROTEIN DESIGN - FROM MOLTEN GLOBULES TO NATIVE-LIKE STATES
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DOI：
10.1016/0959-440x(93)90090-8
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发表时间：
1993-08-01
影响因子：
6.8
通讯作者：
DEGRADO, WF
中科院分区：
文献类型：
--
作者：
BETZ, SF;RALEIGH, DP;DEGRADO, WF
对从头蛋白质设计领域的最新进展进行了综述。根据大多数设计的蛋白质表现出与熔化球体相似的特征的假设，对数据进行了检验。评估了利用定义天然蛋白质的特定相互作用来生产新蛋白质的持续努力，并讨论了这些努力对我们对蛋白质结构、稳定性和折叠的理解的影响。
Recent advances in the field of de novo protein design are examined. The data are examined with respect to the hypothesis that most designed proteins exhibit characteristics similar to those of molten globules. Continuing efforts to produce novel proteins with the specific interactions that define natural proteins are assessed, and the impact that these efforts have had on our understanding of protein structure, stability, and folding is discussed.