Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum.
Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum.
复制标题
DOI：
10.1039/c9cc02524c
复制
发表时间：
2019-08
影响因子：
4.9
通讯作者：
J. Shepherd;Thomas Swift;C. Chang;J. Boyne;S. Rimmer;William H C Martin
中科院分区：
文献类型：
--
作者：
J. Shepherd;Thomas Swift;C. Chang;J. Boyne;S. Rimmer;William H C Martin
细菌群体感应已涉及许多致病细菌过程，如生物膜形成，使其成为开发具有新型抗生素作用模式的材料的关键目标。本文介绍了聚（N-异丙基丙烯酰胺），已被共价连接，在多个链端，高丝氨酸内酯，得到一个高度支化的聚合物功能化的关键信使分子牵连在QS。这种新型功能材料在紫色色杆菌测定中显示出有希望的抗QS活性。
Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.