ON and OFF Unipolar Brush Cells Transform Multisensory Inputs to the Auditory System
ON and OFF Unipolar Brush Cells Transform Multisensory Inputs to the Auditory System
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DOI：
10.1016/j.neuron.2015.02.009
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发表时间：
2015-03-04
期刊：
影响因子：
16.2
通讯作者：
Trussell, Laurence O.
中科院分区：
文献类型：
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作者：
Borges-Merjane, Carolina;Trussell, Laurence O.
耳蜗背核（DCN）和前庭小脑皮质的单极刷状细胞（UBC）接受复杂的刷状树突上的突触能苔藓纤维输入。根据免疫组织化学标记和生理学特征，已经建立了两种UBC亚型，但这些亚型与苔藓纤维输入反应的关系尚不清楚。我们研究了小鼠脑切片中听觉UBC的突触生理学，确定了两种反应谱，并将每种反应谱与特定的UBC亚型相关联。一种亚型具有由AMPAR和mGluR1 α介导的显著双相兴奋性反应。第二个是mGluR1 α负，并占主导地位的强烈抑制外向K+电流。这两种亚型分别上调或下调自发放电。通过与视网膜类比，我们提出UBC包括对谷氨酸能输入反应的ON和OFF细胞，因此可能为其目标提供多感觉输入的独特并行处理。
Unipolar brush cells (UBCs) of the dorsal cochlear nucleus (DCN) and vestibular cerebellar cortex receive glutamatergic mossy fiber input on an elaborate brush-like dendrite. Two subtypes of UBC have been established based on immunohistochemical markers and physiological profiles, but the relation of these subtypes to the response to mossy fiber input is not clear. We examined the synaptic physiology of auditory UBCs in mouse brain slices, identifying two response profiles, and correlated each with a specific UBC subtype. One subtype had a striking biphasic excitatory response mediated by AMPAR and mGluR1 alpha. The second was mGluR1 alpha negative and was dominated by a strongly inhibitory out-ward K+ current. These two subtypes upregulated or downregulated spontaneous firing, respectively. By analogy to the retina, we propose that UBCs comprise ON and OFF cells with respect to their response to glutamatergic input and may therefore provide distinct parallel processing of multisensory input to their targets.