EFFECTS OF IMMOBILIZATION AND FOOD DEPRIVATION ON RAT-BRAIN TRYPTOPHAN METABOLISM
EFFECTS OF IMMOBILIZATION AND FOOD DEPRIVATION ON RAT-BRAIN TRYPTOPHAN METABOLISM
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DOI：
10.1111/j.1471-4159.1972.tb01486.x
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发表时间：
1972-01-01
影响因子：
4.7
通讯作者：
KNOTT, PJ
中科院分区：
文献类型：
--
作者：
CURZON, G;JOSEPH, MH;KNOTT, PJ
禁食或固定均导致大鼠脑色氨酸代谢的变化。脑色氨酸和5-羟吲哚乙酸浓度均升高，而5-羟色胺的变化要小得多。停药后变化更大。大脑色氨酸的变化似乎不仅仅反映了大脑氨基酸浓度的整体增加，大脑酪氨酸浓度仅略有增加，食物戒断和显着降低后固定。血浆色氨酸未增加。脑吲哚代谢的变化并没有被肾上腺切除取消。结果进行了讨论，在有关脑5-羟色胺代谢的调节。
Withdrawal of food or immobilization both led to changes in rat brain tryptophan metabolism. Brain tryptophan and 5‐hydroxyindolylacetic acid concentrations both increased while changes in 5‐hydroxytryptamine were much smaller. Changes were greater upon withdrawal of food. The brain tryptophan change did not appear merely to reflect an overall increase of brain amino acid concentrations, brain tyrosine concentration being only slightly increased by food withdrawal and significantly decreased upon immobilization. Plasma tryptophan did not increase. The changes in brain indole metabolism were not abolished by adrenalectomy. Results are discussed in relation to the regulation of brain serotonin metabolism.