Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: Results from a prospective trial
Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: Results from a prospective trial
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DOI：
10.1080/00365540701756953
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Pithie, Alan
中科院分区：
文献类型：
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作者：
Broom, Jennifer;Woods, Marion;Pithie, Alan
为了评估 70% 乙醇封管加抗生素治疗治疗隧道式中心静脉导管相关血流感染的疗效，前瞻性研究了 19 名患者，使用乙醇封管加抗生素治疗 5 天治疗隧道式中心静脉导管相关菌血症。 12 名患者患有单一微生物感染，7 名患者患有多种微生物分离。 19 名患者中有 17 名完成了乙醇封闭治疗。完成乙醇封管治疗的 17 名患者中有 15 名未出现原微生物复发，并在开始乙醇封管治疗后保留导管中位 36 天，平均 47 天。这些结果证明了该技术对多种潜在有毒生物体的安全性和潜在功效。该干预措施对于工作人员和患者来说都是可以接受的，没有明显的副作用。我们的前瞻性试点研究的初步结果表明，乙醇封管疗法是安全的，易于融入临床实践，并且可能有助于治疗中心静脉导管相关感染，避免需要长期静脉通路的患者拔除导管。
In order to assess the efficacy of 70% ethanol locks in addition to antibiotic therapy to treat tunnelled central venous catheter-associated bloodstream infections, a pilot study of 19 patients was performed prospectively using ethanol locks for 5 d in addition to antibiotic therapy to treat tunnelled central venous catheter-associated bacteraemia. 12 patients had monomicrobial infections and 7 had polymicrobial isolates. 17 of 19 patients completed ethanol lock therapy. 15 of 17 patients completing ethanol lock therapy had no recurrence of the original organism and retained their catheter for a median of 36 and an average of 47 d following initiation of ethanol lock therapy. These results demonstrate the safety and potential efficacy of this technique against a broad range of potentially virulent organisms. The intervention was acceptable to both staff and patients with no significant side-effects. These preliminary results from our prospective pilot study suggest that ethanol lock therapy is safe and easily integrated into clinical practice, and may have utility in treating central venous catheter-associated infections, avoiding removal of catheters in patients requiring long-term venous access.