Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole
Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole
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卡泊芬净和伏立康唑联合治疗成功治疗肝移植受者的深部窦曲霉病
DOI：
10.1111/j.1399-3062.2004.00039.x
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发表时间：
2004
影响因子：
2.6
通讯作者：
E. K. Manesis
中科院分区：
文献类型：
--
作者：
S. Tsiodras;R. Zafiropoulou;J. Giotakis;G. Imbrios;A. Antoniades;E. K. Manesis
摘要：我们描述了一例罕见的糖尿病患者，该患者在丙型肝炎病毒相关肝硬化肝移植后成功治疗了巨细胞病毒病毒血症和利什曼病，但仍在使用脂质体阿替霉素B（AmBisome）时发生了侵袭性窦曲霉菌感染。患者拒绝接受包括眼球摘除在内的根治性手术，并接受静脉注射卡泊芬净和伏立康唑联合治疗，并沿着反复的保守局部手术清创。在鼻窦炎发作后15个月的随访中，患者保持培养阴性，完全活跃，并且没有局部复发的证据。
Abstract: We describe the rare case of a diabetic patient who was successfully treated for cytomegalovirus viremia and leishmaniasis following liver transplantation for hepatitis C virus‐related cirrhosis, but also developed invasive sinus Aspergillus infection, while still on liposomal amphotericin B (AmBisome). The patient refused radical surgery including eye enucleation, and received a combination of intravenous caspofungin and voriconazole, along with repeated, conservative, local surgical debridement. At follow‐up, 15 months after the onset of sinusitis, the patient remains culture‐negative, fully active, and without evidence of local recurrence.
影响因子：
6.4
作者：
Petraitis, V;Petraitiene, R;Walsh, TJ
通讯作者：
Walsh, TJ
影响因子：
158.5
作者：
Herbrecht, R;Denning, DW;de Pauw, B
通讯作者：
de Pauw, B