Highly enantioselective synthesis of tertiary alcohols: C2-symmetric N,N'-dioxide-Sc(III) complex promoted direct aldol reaction of alpha-ketoesters and diazoacetate esters.
Highly enantioselective synthesis of tertiary alcohols: C2-symmetric N,N'-dioxide-Sc(III) complex promoted direct aldol reaction of alpha-ketoesters and diazoacetate esters.
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DOI：
10.1039/b913520k
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发表时间：
2009-11
影响因子：
4.9
通讯作者：
Fei Wang;Xiaohua Liu;Yulong Zhang;Lili Lin;Xiaoming Feng
中科院分区：
文献类型：
--
作者：
Fei Wang;Xiaohua Liu;Yulong Zhang;Lili Lin;Xiaoming Feng
合成了一种C(2)对称的N，N‘-二氧化物-Sc(III)配合物，用于催化α-酮酯和重氮乙酸酯的不对称Aldol反应，合成了产率高、对映选择性好的叔醇。
A C(2)-symmetric N,N'-dioxide-Sc(III) complex has been developed to promote the asymmetric catalytic aldol reaction of alpha-ketoesters and diazoacetate esters to afford tertiary alcohols in good yields with excellent enantioselectivities.