White matter microstructure in opiate addiction
White matter microstructure in opiate addiction
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DOI：
10.1111/j.1369-1600.2010.00266.x
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发表时间：
2012-01-01
影响因子：
3.4
通讯作者：
Lubman, Dan I.
中科院分区：
文献类型：
--
作者：
Bora, Emre;Yuecel, Murat;Lubman, Dan I.
海洛因成瘾与神经元连接受损和认知缺陷有关。一种可能解释这些发现的机制是继发于长期使用阿片类药物的白色物质连接的改变。然而，很少有研究定量研究阿片成瘾（OA）的白色物质赤字。在这里，我们研究了白色物质的微观结构在OA扩散张量成像（DTI）。我们对24名OA患者和29名健康对照者进行了分数各向异性（FA）的体素分析。OA组显示多个通路的FA减少，包括胼胝体、丘脑放射和下纵束。这种FA减少主要是由于径向扩散率（？？）增加，表明髓鞘病变。OA持续时间较长也与轴突扩散率（？）1），在上级纵束和右额叶白色物质中最强烈，表明长期使用者的轴突损伤。总之，研究结果表明，长期使用OA对神经元连接和功能具有广泛而多样的影响。
Heroin addiction has been associated with impaired neuronal connectivity and cognitive deficits. One mechanism that potentially explains these findings is alterations in white matter connectivity secondary to chronic opiate use. However, few studies have quantitavely examined white matter deficits in opiate addiction (OA). Here, we investigated white matter microstructure in OA using diffusion tensor imaging (DTI). We performed voxel-wise analysis of fractional anisotropy (FA) in 24 participants with OA and 29 healthy controls. The OA group showed reduced FA in multiple pathways including the corpus callosum, thalamic radiation and inferior longitudinal fasciculus. This FA reduction was mainly the result of increased radial diffusivity (??), indicative of myelin pathology. Longer duration of OA was also associated with axonal diffusivity (?1), most robustly in superior longitudinal fasciculi and right frontal white matter suggesting axonal injury in long-term users. Together, the findings indicate that chronic OA use has widespread and diverse effects on neuronal connectivity and function.