A highly selective catalytic method for the oxidative functionalization of C-H bonds
A highly selective catalytic method for the oxidative functionalization of C-H bonds
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DOI：
10.1021/ja031543m
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发表时间：
2004-03-03
影响因子：
15
通讯作者：
Sanford, MS
中科院分区：
文献类型：
--
作者：
Dick, AR;Hull, KL;Sanford, MS
本文描述了一种新的高度实用的Pd（II）催化方法，用于芳烃和烷烃的区域和化学选择性氧化功能化。含有多种导向基团（如吡啶、偶氮苯、吡唑和亚胺衍生物）的底物的碳-氢键在温和条件下选择性地转化为酯类、醚类和芳基卤化物。从底物、导向基团和氧化剂的角度描述了该反应的范围，并提出了一个初步的催化循环。
This communication describes a new and highly practical Pd(II)-catalyzed method for the regio- and chemoselective oxidative functionalization of arenes and alkanes. Carbon−hydrogen bonds of substrates that contain a variety of directing groups (e.g., pyridine, azobenzene, pyrazole, and imine derivatives) are selectively transformed into esters, ethers, and aryl-halides under mild conditions. The scope of this reaction in terms of substrate, directing group, and oxidant is described, and a preliminary catalytic cycle is proposed.