Elevated serum granulocyte-macrophage colony-stimulating factor levels during radiotherapy predict favorable outcomes in lung and esophageal cancer.
Elevated serum granulocyte-macrophage colony-stimulating factor levels during radiotherapy predict favorable outcomes in lung and esophageal cancer.
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放疗期间血清粒细胞-巨噬细胞集落刺激因子水平升高预示着肺癌和食管癌的良好结局
DOI：
10.18632/oncotarget.13202
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发表时间：
2016-12-20
期刊：
影响因子：
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通讯作者：
Zhang J
中科院分区：
文献类型：
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作者：
Deng G;Hu P;Zhang J;Liu Q;Liang N;Xie J;Qiao L;Luo H;Xu D;Liu F;Yu X;Liu Z;Lv Y;Zhang J
外源性粒细胞-巨噬细胞集落刺激因子（GM-CSF）与放疗（RT）联合应用已被证明可以增强抗肿瘤免疫反应。我们推测，在RT期间GM-CSF的变化与癌症预后相关。我们检测了126例不能手术切除的肺癌和食管癌患者在放疗前和放疗中的血清GM-CSF和IFN-γ水平，并进行了生存分析。RT期间GM-CSF水平上调与较长的总生存期（OS）和无进展生存期（PFS）相关。另一方面，在不同IFN-γ水平下未观察到OS或PFS差异。然而，“综合因子”（计算为高RT前IFN-γ水平和上调的GM-CSF的组合）与OS和PFS延长相关。多因素分析显示，GM-CSF水平和综合因素均是较疾病分期更强的独立预后因素。这些数据表明，在RT期间GM-CSF水平可用作肺癌和食管癌的预后生物标志物。
The combination of exogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) with radiotherapy (RT) has been demonstrated to strengthen the antitumor immune response. We hypothesized that the variation of GM-CSF during RT was correlated with cancer prognosis. We measured serum levels of GM-CSF and interferon-γ (IFN-γ) before and during RT in 126 unresectable lung and esophageal cancer patients and performed survival analyses. Upregulated GM-CSF levels during RT correlated with longer overall survival (OS) and progression-free survival (PFS). On the other hand, no difference in OS or PFS was seen at different IFN-γ levels. However, the “integrated factor”, computed as the combination of high pre-RT IFN-γ levels and upregulated GM-CSF, correlated with prolonged OS and PFS. Multivariate analyses revealed that GM-CSF levels and the integrated factor were both stronger independent prognostic factors than disease stage. These data demonstrate that GM-CSF levels during RT can be used as a prognostic biomarker for lung and esophageal cancer.