Hepatocyte growth factor scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons
Hepatocyte growth factor scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons
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DOI：
10.1016/s0896-6273(00)80247-0
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发表时间：
1996-12-01
期刊：
影响因子：
16.2
通讯作者：
TessierLavigne, M
中科院分区：
文献类型：
--
作者：
Ebens, A;Brose, K;TessierLavigne, M
在胚胎神经系统中，发育中的轴突可被其中间和最终细胞靶点所分泌的扩散性因子引导至其靶点。到目前为止，仅发现了一个对发育中轴突起化学吸引作用的家族。在鱼类、两栖类和鸟类中进行的移植和切除实验表明，脊髓运动轴突部分是被由生骨节和肢体间充质产生的一系列化学吸引物引导至肢体中的靶点的，这两个是轴突在通往其靶肌肉途中遇到的中间靶点。在此我们将肢体间充质衍生的化学吸引物确定为肝细胞生长因子/散射因子（HGF/SF），它是c - Met受体酪氨酸激酶的一种可扩散配体，并且我们还表明在后期HGF/SF作为运动神经元的一种肌肉衍生的存活因子起作用。这些结果表明，除了在非神经系统中作为有丝分裂原、运动原和形态发生素发挥作用外，HGF/SF还可在发育中的神经系统中作为一种导向和存活因子发挥作用。
In the embryonic nervous system, developing axons can be guided to their targets by diffusible factors secreted by their intermediate and final cellular targets. To date only one family of chemoattractants for developing axons has been identified. Grafting and ablation experiments in fish, amphibians, and birds have suggested that spinal motor axons are guided to their targets in the limb in part by a succession of chemoattractants made by the sclerotome and by the limb mesenchyme, two intermediate targets that these axons encounter en route to their target muscles. Here we identify the limb mesenchyme-derived chemoattractant as hepatocyte growth factor/scatter factor (HGF/SF), a diffusible ligand for the c-Met receptor tyrosine kinase, and we also implicate HGF/SF at later stages as a muscle-derived survival factor for motoneurons. These results indicate that, in addition to functioning as a mitogen, a motogen, and a morphogen in nonneural systems, HGF/SF can function as a guidance and survival factor in the developing nervous system.