FAMILIAL OCCURRENCE OF ATOPIC DISEASE - GENETIC VERSUS ENVIRONMENTAL-FACTORS
FAMILIAL OCCURRENCE OF ATOPIC DISEASE - GENETIC VERSUS ENVIRONMENTAL-FACTORS
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DOI：
10.1111/j.1365-2222.1993.tb00260.x
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发表时间：
1993-10-01
影响因子：
6.1
通讯作者：
ABERG, N
中科院分区：
文献类型：
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作者：
ABERG, N
通过对19814年（7岁、10岁和14岁）瑞典学龄儿童及其父母的问卷调查，研究了特应性疾病（哮喘/喘息性支气管炎、过敏性鼻炎、湿疹和荨麻疹的任何报告症状）的累积生活患病率。发现母亲病史是父亲病史的两倍。受影响母亲的子女与受影响父亲的子女患特应性疾病的比例相同，受影响母亲的子女比受影响父亲的子女多出一倍。父母对儿童疾病影响最大的是多种症状和父母双方的一致症状。父母双方都受到影响的孩子数量是预期的1.6倍。讨论了多基因遗传中可能存在的剂量反应效应，以及具有家族聚类倾向的环境因素的假设影响。
Cumulative life prevalence of atopic disease (any of reported symptoms of asthma/wheezy bronchitis, allergic rhinitis, eczema and urticaria) was studied by means of a questionnaire in 19814 (7-, 10- and 14-year-old) Swedish school children and their parents. Maternal history was found to be twice as common as paternal history. The children of affected mothers contracted atopic disease in the same proportion as the children of affected fathers yielding twice as many affected children with affected mothers than with affected fathers. The strongest parental influence on childhood disease was seen for multiple symptoms and for congruent symptoms with both parents. The number of children with both parents affected was 1.6 times larger than expected. A possible dose-response effect in polygenic inheritance is discussed as well as assumed impact of environmental factors with a tendency to familial clustering.