SILICON - A REQUIREMENT IN BONE-FORMATION INDEPENDENT OF VITAMIN-D1
SILICON - A REQUIREMENT IN BONE-FORMATION INDEPENDENT OF VITAMIN-D1
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DOI：
10.1007/bf02409409
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发表时间：
1981-01-01
影响因子：
4.2
通讯作者：
CARLISLE, EM
中科院分区：
文献类型：
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作者：
CARLISLE, EM
在微量元素控制条件下，给1日龄公鸡饲喂低硅和补硅日粮中添加适量维生素D和不添加维生素D。在4wk结束时，饲喂维生素D3(600IU)的雏鸡具有最佳的生长速度，而添加D2(6000IU)和不添加维生素D的雏鸡的生长速度明显降低。在相同的维生素D水平上，缺硅和补硅雏鸡的生长没有显着差异，头骨大小与雏鸡的总体生长速度成正比。所有饲喂低硅日粮的雏鸡，无论饲料中维生素D的水平如何，都会出现严重的颅骨结构异常，总体头骨外观变窄和变短。额区变窄，顶前交界处背侧正中线压低，后侧变窄，顶枕区发育迟缓。这些异常区域表现为较少的小梁和较少的钙化。对颅骨的氨基己糖、胶原、非胶原蛋白和骨矿物质的分析表明，主要差异在于胶原含量，缺乏硅的头骨在各个水平的维生素D中胶原含量明显减少。硅对骨基质的影响不依赖维生素D。硅参与了骨形成的早期阶段。
Day old cockerels were fed Si-deficient and Si-supplemented diets with adequate and no dietary vitamin D under trace element controlled conditions. At the end of 4 wk chicks receiving dietary vitamin D3 (600 IU) exhibited optimal rates of growth; the growth rates of chicks receiving D2 (6000 IU) and no vitamin D were markedly depressed. There were no significant differences between growth of Si-deficient and Si-supplemented chicks on the same level of vitamin D. Skull and bone size was proportional to overall chick growth. All chicks on Si-deficient diets irrespective of the level of dietary vitamin D had gross abnormalities of skull architecture, the overall skull appearance being narrower and shorter. The frontal area was narrower and the dorsal median line at the front parietal junction was depressed with a narrowing both posterior and laterally, stunting parietal and occipital areas. These abnormal areas showed fewer trabeculae and less calcification. Analyses of skull frontal bones for hexosamine, collagen, noncollagenous protein and bone mineral demonstrated that the major difference was in collagen content, the Si-deficient skulls showing considerably less collagen at each level of vitamin D. Si has a significant effect on the bone matrix independent of vitamin D. Si is involved in an early stage of bone formation.