Microphysiology of Epileptiform Activity in Human Neocortex
Microphysiology of Epileptiform Activity in Human Neocortex
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DOI：
10.1097/wnp.0b013e31818e8010
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发表时间：
2008-12-01
影响因子：
2.4
通讯作者：
Emerson, Ronald G.
中科院分区：
文献类型：
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作者：
Schevon, Catherine A.;Ng, Sau K.;Emerson, Ronald G.
作者报告使用密集的二维微电极阵列记录来表征癫痫发生的人类皮层的细分辨率皮层电活动（“mu EEG”）。对5例难治性癫痫患者进行有创脑电图监测，植入16 mm(2) 96微电极阵列，电极间距400 μ m。从合金中获得的高空间分辨率数据与同时获得的标准颅内电极网格和条带数据进行了分析。从癫痫区记录的mu脑电图显示放电类似于间歇癫痫样活动（“微放电”）和电图癫痫发作（“微癫痫”），但仅限于小至200 mu m的皮质区域(2)。两个病人。这种活动似乎与电痉挛的开始或传播有关。作者推测，微放电和微癫痫发作是由形成致痫皮层底物的小皮质区域产生的，并在癫痫发作的开始和传播中起重要作用。和传播。
The authors report the use of dense two-dimensional microelectrode array recordings to characterize fine resolution electrocortical activity ("mu EEG") in epileptogenic human cortex. A 16-mm(2) 96 microelectrode array with 400-mu m interelectrode spacing was implanted in five patients undergoing invasive EEG monitoring for medically refractory epilepsy. High spatial resolution data from the allay were analyzed in conjunction with simultaneously acquired data from standard intracranial electrode grids and strips. mu EEG recorded from within the epileptogenic zone demonstrates discharges resembling both interictal epileptiform activity ("microdischarges") and electrographic seizures ("microseizures") but confined to cortical regions as small as 200 mu m(2). In two patients. this activity appeared to be involved in the initiation or propagation of electrographic seizures. The authors hypothesize that microdischarges and microseizures are generated by small cortical domains that form the substrate of epileptogenic cortex and play important roles in seizure initiation and propagation. and propagation.