A Randomized Controlled Trial Translating the Diabetes Prevention Program to a University Worksite, Ohio, 2012-2014.
A Randomized Controlled Trial Translating the Diabetes Prevention Program to a University Worksite, Ohio, 2012-2014.
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DOI：
10.5888/pcd12.150301
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发表时间：
2015-11-25
影响因子：
5.5
通讯作者：
Gascon GM
中科院分区：
文献类型：
--
作者：
Weinhold KR;Miller CK;Marrero DG;Nagaraja HN;Focht BC;Gascon GM
工作的成年人花很多时间在工作场所，这是针对减肥和预防疾病的健康计划的理想环境。很少有随机试验评估工作场所糖尿病预防计划的有效性。本研究评估了与常规护理相比，工作场所生活方式干预对代谢和行为危险因素的有效性。采用前测-后测对照组设计，随访3个月。糖尿病前期患者从大学工地招募，随机接受16周的生活方式干预（n = 35）或常规护理（n = 34）。在基线、干预后和3个月随访时对参与者进行评估。饮食摄入量通过食物频率调查问卷测量，身体活动水平通过加速度计测量。重复测量方差分析比较了组间和组内结果的变化。干预组的平均（标准误[SE]）体重减轻（-5.5%[0.6%]）大于对照组（-0.4%[0.5%]）（P <0.001），并在3个月随访时持续（P <0.001）。干预后，干预组空腹血糖的平均（SE）降低（-8.6 [1.6] mg/dL）大于对照组（-3.7 [1.6] mg/dL）（P = .02）;两组在3个月随访时血糖均显著降低（P < .001）。在干预组中，干预后总能量摄入量和来自所有脂肪、饱和脂肪和反式脂肪的能量百分比下降，膳食纤维摄入量增加（均P <0.01）。工作场所干预改善了糖尿病前期员工的代谢和行为风险因素。对糖尿病预防和项目可持续性的长期影响值得进一步研究。
Working adults spend much time at the workplace, an ideal setting for wellness programs targeting weight loss and disease prevention. Few randomized trials have evaluated the efficacy of worksite diabetes prevention programs. This study evaluated the efficacy of a worksite lifestyle intervention on metabolic and behavioral risk factors compared with usual care. A pretest–posttest control group design with 3-month follow-up was used. Participants with prediabetes were recruited from a university worksite and randomized to receive a 16-week lifestyle intervention (n = 35) or usual care (n = 34). Participants were evaluated at baseline, postintervention, and 3-month follow-up. Dietary intake was measured by a food frequency questionnaire and level of physical activity by accelerometers. Repeated measures analysis of variance compared the change in outcomes between and within groups. Mean (standard error [SE]) weight loss was greater in the intervention (−5.5% [0.6%]) than in the control (−0.4% [0.5%]) group (P < .001) postintervention and was sustained at 3-month follow-up (P < .001). Mean (SE) reductions in fasting glucose were greater in the intervention (−8.6 [1.6] mg/dL) than in the control (−3.7 [1.6] mg/dL) group (P = .02) postintervention; both groups had significant glucose reductions at 3-month follow-up (P < .001). In the intervention group, the intake of total energy and the percentage of energy from all fats, saturated fats, and trans fats decreased, and the intake of dietary fiber increased (all P < .01) postintervention. The worksite intervention improved metabolic and behavioral risk factors among employees with prediabetes. The long-term impact on diabetes prevention and program sustainability warrant further investigation.