Reduction of syndecan-1 expression is associated with dysplastic oral epithelium.
Reduction of syndecan-1 expression is associated with dysplastic oral epithelium.
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syndecan-1 表达的减少与口腔上皮发育不良有关。
DOI：
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发表时间：
2000
影响因子：
3.3
通讯作者：
R. Happonen
中科院分区：
文献类型：
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作者：
T. Soukka;J. Pohjola;P. Inki;R. Happonen
多配体聚糖是参与细胞-基质相互作用和生长因子结合的完整膜蛋白聚糖家族。Syndecan-1表达在角质形成细胞分化过程中被诱导，在鳞状细胞癌中被降低。本研究的目的是研究syndecan-1在口腔上皮异常增生中的表达变化。本文应用免疫组化方法对66例口腔粘膜活检标本（上皮不典型增生43例，原位癌3例，鳞状细胞癌20例）进行了研究。正常上皮标本syndecan-1呈高阳性。46例异型增生或原位癌标本中有15例syndecan-1呈阴性或弱阳性，其中2例完全阴性。分别在17例和14例发育不良或原位癌标本中观察到中等和强染色。13例（65%）鳞状细胞癌syndecan-1呈阴性或弱阳性，其中7例完全阴性。只有三个癌有很强的syndecan-1表达。随访的34例异型增生患者中有4例发展为鳞状细胞癌。所有这些发育不良有弱或完全阴性syndecan-1的表达。结果表明，syndecan-1的丢失与口腔上皮的发育异常变化有关。
Syndecans are a family of integral membrane proteoglycans that participate in cell-matrix interactions and growth factor binding. Syndecan-1 expression is induced during keratinocyte differentiation and reduced in squamous cell carcinomas. The purpose of this study was to examine the alteration in syndecan-1 expression in dysplastic oral epithelium. Sixty-six oral biopsy specimens (43 epithelial dysplasias, 3 carcinoma in situ and 20 squamous cell carcinomas) were studied using immunohistochemical methods. The normal epithelium specimens were highly positive for syndecan-1. Fifteen of 46 dysplasias or carcinoma in situ specimens showed negative or weak staining for syndecan-1, two of which were totally negative. Intermediate and strong staining were observed in 17 and 14 dysplasias or carcinoma in situ specimens, respectively. Thirteen (65%) squamous cell carcinomas showed negative or weak staining for syndecan-1, seven of which were totally negative. Only three carcinomas had a strong syndecan-1 expression. Four of the 34 patients with dysplasia who were followed up developed squamous cell carcinoma. All these dysplasias had weak or totally negative syndecan-1 expression. The results suggest that the loss of syndecan-1 is associated with dysplastic changes in oral epithelium.