The metabolism of lymphomas
The metabolism of lymphomas
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DOI：
10.1097/moh.0b013e3283623d16
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发表时间：
2013-07-01
影响因子：
3.2
通讯作者：
Cerchietti, Leandro
中科院分区：
文献类型：
--
作者：
Calvo-Vidal, M. Nieves;Cerchietti, Leandro
综述的目的从细胞到动物再到人类的研究揭示了有助于维持淋巴瘤发生的代谢途径。老球员与新的代谢技巧和新的代谢球员进入现场。这篇综述的目的是讨论淋巴瘤代谢领域取得的最新进展，特别关注肿瘤促进和抑制途径的代谢调节，相反，这些途径对代谢物addiction.Recent findingsThe的基础上的代谢物addiction.Recent findingsThe淋巴瘤细胞中的高葡萄糖摄取和糖酵解活性现在开始被理解。最近的研究结果表明，核苷酸生物合成作为糖酵解的主要驱动力，特别是在增殖和细胞应激条件下，发挥更大的作用。有新的证据表明，甘氨酸-叶酸代谢失调在核苷酸生物合成、基因组完整性和表观遗传维持中的贡献越来越大。已经描述了MYC、PI 3 K和TP 53在调节淋巴瘤细胞中的活性氧产生、糖酵解和氨解中的扩展作用。新途径的鉴定已经允许出现新的抗代谢物的策略，以增加当前approaches.SummaryMetabolism的治疗效果，淋巴瘤必须满足细胞增殖和淋巴瘤特异性的一般要求。来自临床前研究的数据正在阐明有助于维持淋巴瘤恶性表型的代谢途径。这导致了新途径的鉴定，其中一些可能在淋巴瘤亚型的诊断、表征和治疗中具有临床影响。
Purpose of reviewCellular to animal to human studies are shedding light on metabolic pathways that contribute to sustaining lymphomagenesis. Old players with new metabolic tricks and new metabolic players come into the scene. The purpose of this review is to discuss the recent advances made in the field of lymphoma metabolism with special focus on the metabolic modulation of tumor promoting and suppressing pathways and, conversely, on the effect of these pathways on metabolite addiction.Recent findingsThe basis for the high glucose uptake and glycolytic activity in lymphoma cells is now beginning to be understood. Recent findings suggest a greater role of nucleotide biosynthesis as a major driving force for glycolysis, especially during proliferation and cellular stress conditions. There is new evidence for an increasing contribution of glycine-folate metabolism deregulation in nucleotide biosynthesis, genome integrity and epigenetic maintenance. Expanding roles for MYC, PI3K and TP53 in regulating reactive oxygen production, glycolysis and glutaminolysis in lymphoma cells have been described. The identification of novel pathways has allowed the emergence of new antimetabolite' strategies to increase the therapeutic efficacy of current approaches.SummaryMetabolism in lymphomas must fulfill the general demands from cell proliferation and those specific to lymphomagenesis. Data emerging from preclinical studies are elucidating the metabolic pathways that contribute to maintaining the malignant phenotype in lymphomas. This has resulted in identification of novel pathways, some of which may have a clinical impact in the diagnosis, characterization and treatment of lymphoma subtypes.