The study on the association between Beijing genotype family and drug susceptibility phenotypes of Mycobacterium tuberculosis in Beijing.
The study on the association between Beijing genotype family and drug susceptibility phenotypes of Mycobacterium tuberculosis in Beijing.
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DOI：
10.1038/s41598-017-14119-z
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发表时间：
2017-11-08
影响因子：
4.6
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Liu Y;Jiang X;Li W;Zhang X;Wang W;Li C
北京地区结核分枝杆菌（M. tb）主要流行系为北京基因型家族。北京基因型与耐药之间的关系尚无系统的研究。这里我们收集了268 M。对结核菌株的背景资料和细菌学特征进行了分析。病例平均年龄40.12岁；男性患者几乎是女性患者的三倍。经基因分型分析，81.7%（219/268）株为北京基因型；北京基因型与非北京基因型患者在性别、年龄和治疗史上无显著差异。药敏试验（DST）分析显示，172株（64.2%）对异烟肼、利福平、链霉素和乙胺丁醇全部敏感，96株（35.8%）对至少一种药物耐药。北京基因型菌株的聚类率显著高于北京基因型。但北京基因型家族与耐药关系不明显。该研究揭示了北京基因型菌株的基因型多样性和耐药频率。这将有助于北京市建立有效的结核病防治策略。
The predominant prevalent Mycobacterium tuberculosis (M. tb) lineage was the Beijing genotype family in Beijing. There has been no systematic study on the association between drug resistance and Beijing genotype. Here we collected 268 M. tb strains, analyzed the background information and the bacteriological characteristics. The mean age of the cases was 40.12 years; male patients were almost three times than female patients. After genotyping analyzation, 81.7% (219/268) strains were categorized as Beijing genotype; no significant difference was observed between Beijing and non-Beijing genotype in gender, age and treatment history. Drug susceptibility testing (DST) analyzation demonstrated that 172 (64.2%) strains were fully sensitive to all drugs (Isoniazid, Rifampin, Streptomycin, and Ethambutol), while 96 (35.8%) strains were resistant to at least one of the drugs. Beijing genotype strains exhibited a significantly higher clustering rate. However, no significant association relationship was observed between drug resistance and Beijing genotype family. The study provided insights into the genotype diversity and revealed that the frequencies of drug-resistance of Beijing genotype strains.It would be helpful for the establishment of the efficient tuberculosis (TB) prevention and control strategy in Beijing.
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影响因子：
2.5
作者：
Ma, Yan;Pang, Yu;Gao, Weiwei
通讯作者：
Gao, Weiwei
影响因子：
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作者：
Aldous, WK;Pounder, JI;Woods, GL
通讯作者：
Woods, GL
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影响因子：
11.8
作者：
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通讯作者：
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通讯作者：
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作者：
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通讯作者：
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