Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information.
Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information.
复制标题
脊髓连合中间神经元在对侧感觉信息传递中的独特作用。
DOI：
10.1016/j.cub.2023.07.014
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Akay,Turgay
中科院分区：
文献类型：
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作者：
Laflamme,OlivierD;Markin,SergeyN;Deska-Gauthier,Dylan;Banks,Rachel;Zhang,Ying;Danner,SimonM;Akay,Turgay
交叉反射是由连合通路介导的，该通路将感觉信息传递到身体的对侧，但其基础网络尚未完全了解。在小鼠运动过程中协调脊髓运动回路活动的连合通路已被表征，但它们与交叉反射的关系尚不清楚。我们发现参与两个遗传上不同的群体连合中间神经元（CINs）描述的小鼠，V0和V3 CINs，在交叉反射通路。我们的数据表明，完全兴奋性V3 CINs直接参与兴奋性交叉反射，并表明它们是必不可少的抑制性交叉反射。相比之下，V0 CINs，一个包括兴奋性和抑制性CINs的群体，不直接参与兴奋性或抑制性交叉反射，但下调抑制性交叉反射。我们的数据提供了对小鼠交叉反射的脊髓回路的深入了解，描述了V0和V3 CINs在交叉反射中的作用。
Crossed reflexes are mediated by commissural pathways transmitting sensory information to the contralateral side of the body, but the underlying network is not fully understood. Commissural pathways coordinating the activities of spinal locomotor circuits during locomotion have been characterized in mice, but their relationship to crossed reflexes is unknown. We show the involvement of two genetically distinct groups of commissural interneurons (CINs) described in mice, V0 and V3 CINs, in the crossed reflex pathways. Our data suggest that the exclusively excitatory V3 CINs are directly involved in the excitatory crossed reflexes and show that they are essential for the inhibitory crossed reflexes. In contrast, the V0 CINs, a population that includes excitatory and inhibitory CINs, are not directly involved in excitatory or inhibitory crossed reflexes but downregulate the inhibitory crossed reflexes. Our data provide insights into the spinal circuitry underlying crossed reflexes in mice, describing the roles of V0 and V3 CINs in crossed reflexes.