DDT AND RELATED-COMPOUNDS AND RISK OF PANCREATIC-CANCER
DDT AND RELATED-COMPOUNDS AND RISK OF PANCREATIC-CANCER
复制标题
DOI：
10.1093/jnci/84.10.764
复制
发表时间：
1992-05-20
期刊：
影响因子：
--
通讯作者：
MACK, TM
中科院分区：
文献类型：
--
作者：
GARABRANT, DH;HELD, J;MACK, TM
背景：1987年完成的一项针对5886名化学制造工人的队列死亡率研究显示，胰腺癌导致的死亡率增加。目的：我们在这些化学品制造工人中进行了一项胰腺癌的嵌套病例对照研究，以确定该疾病的危险因素。方法：对28例确诊的胰腺癌患者和112例正常对照进行研究。对每个受试者的近亲进行了访谈，以确定生活方式因素，包括吸烟、饮酒和咖啡消费。使用书面工作记录和对同事的采访来确定正在研究的工厂的化学暴露情况。结果：DDT与胰腺癌相关(曾经接触与从未接触的风险比[RR]=4.8；95%可信区间=1.3~17.6)。在平均接触滴滴涕47个月的受试者中，风险是没有接触的受试者的7.4倍。两种滴滴涕衍生物乙基兰和滴滴涕还与胰腺癌有关(RR分别为5.0和4.3)；接触这两种化学物质是相关的，无法确定它们是否相互独立起作用。吸烟被确定为一个独立的危险因素，但在分析中控制吸烟(和其他潜在的混杂因素)并没有明显改变DDT、DDD或乙烯的风险。结论：暴露于DDT与胰腺癌有关。这种联系不能用生活方式因素或其他化学物质的暴露来解释，风险随着暴露的时间和自第一次暴露以来的潜伏期而增加。这些结果可能表明，在大量和长时间暴露的情况下，DDT可能会导致人类胰腺癌。
Background: A cohort mortality study among 5886 chemical manufacturing workers was completed in 1987 and showed increased mortality due to pancreatic cancer. Purpose: We conducted a nested case-control study of pancreatic cancer among these chemical manufacturing workers to identify risk factors for this disease. Methods: Twenty-eight verified cases of pancreatic cancer and 112 matched controls were studied. Next of kin of each subject were interviewed to determine lifestyle factors, including tobacco, alcohol, and coffee consumption. Written work records and interviews with co-workers were used to determine chemical exposures at the plant under study. Results: DDT was associated with pancreatic cancer (risk ratio [RR] for ever exposed compared with never exposed = 4.8; 95% confidence interval = 1.3-17.6). Among subjects who had a mean exposure to DDT of 47 months, the risk was 7.4 times that among subjects with no exposure. Two DDT derivatives, Ethylan and DDD, were additionally associated with pancreatic cancer (RR = 5.0 and 4.3, respectively); exposures to these two chemicals were correlated, and it was not possible to determine whether each acted independently of the other. Smoking was identified as an independent risk factor, but controlling for smoking (and other potential confounders) in the analyses did not appreciably alter the risks seen for DDT, DDD, or Ethylan. Conclusions: Exposure to DDT was associated with pancreatic cancer. The association was not explained by exposure to lifestyle factors or other chemicals, and risk increased with both duration of exposure and latency since first exposure. Implications: These results may indicate that DDT can cause pancreatic cancer in humans under circumstances of heavy and prolonged exposure.