Effect of short- and long-term heat exposure on brain monoamines and emotional behavior in mice and rats
Effect of short- and long-term heat exposure on brain monoamines and emotional behavior in mice and rats
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DOI：
10.1016/j.jtherbio.2021.102923
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发表时间：
2021-04-22
影响因子：
2.7
通讯作者：
Ishiwata，Takayuki
中科院分区：
文献类型：
--
作者：
Nakagawa，Hikaru;Ishiwata，Takayuki
热暴露影响几种生理、神经和情感功能。值得注意的是，大脑中的单胺能神经递质，如去甲肾上腺素，多巴胺和血清素，调节几个基本的生理功能，如体温调节，食物摄入和能量平衡，受到热暴露和热适应的影响。此外，认知和情绪状态也受到热暴露和大脑单胺水平变化的影响。据报道，在一些行为测试中，短期的热暴露会增加焦虑。相比之下，有一种可能性，即长期热暴露减少焦虑由于热适应。这些变化可能是由于热暴露对核心体温和/或脑单胺水平的适应。在这篇综述中，我们首先概述了大脑单胺水平的变化，然后重点关注热暴露和热适应引起的情绪行为的变化。最后，我们描述了热习服过程中情绪行为和脑单胺水平之间的关系。
Heat exposure affects several physiological, neuronal, and emotional functions. Notably, monoaminergic neurotransmitters in the brain such as noradrenaline, dopamine, and serotonin, which regulate several basic physiological functions, such as thermoregulation, food intake, and energy balance, are affected by heat exposure and heat acclimation. Furthermore, cognition and emotional states are also affected by heat exposure and changes in brain monoamine levels. Short-term heat exposure has been reported to increase anxiety in some behavioral tests. In contrast, there is a possibility that long-term heat exposure decreases anxiety due to heat acclimation. These changes might be due to adaptation of the core body temperature and/or brain monoamine levels by heat exposure. In this review, we first outline the changes in brain monoamine levels and thereafter focus on changes in emotional behavior due to heat exposure and heat acclimation. Finally, we describe the relationships between emotional behavior and brain monoamine levels during heat acclimation.