Pd‐Catalyzed Synthesis of α‐Aryl Vinylphosphonates via Suzuki Arylation of α‐Phosphonovinyl Nonaflates
Pd‐Catalyzed Synthesis of α‐Aryl Vinylphosphonates via Suzuki Arylation of α‐Phosphonovinyl Nonaflates
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DOI：
10.1002/cjoc.201500414
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发表时间：
2015-10
影响因子：
5.4
通讯作者：
M. Yuan;Yewen Fang;Li Zhang;Xiaoping Jin;Minjia Tao;Qilin Ye;Ruifeng Li;Jinjian Li;Hui Zheng;Juejun Gu
中科院分区：
文献类型：
--
作者：
M. Yuan;Yewen Fang;Li Zhang;Xiaoping Jin;Minjia Tao;Qilin Ye;Ruifeng Li;Jinjian Li;Hui Zheng;Juejun Gu
本文报道了第一种钯催化的α-膦基十九烷基酯的芳基化反应。使用Pd(OAc)2和SPHOS组成的催化剂，可以在温和的条件下有效地获得末端和内部的α-芳基乙烯基膦酸酯。该反应具有广泛的偶联伙伴范围，并能容忍许多官能团。
The first palladium-catalyzed method for the arylation of α-phosphonovinyl nonaflates is described. Using a catalyst comprised of Pd(OAc)2 and SPhos, terminal and internal α-aryl vinylphosphonates could be efficiently accessed under mild conditions. The reaction features a broad coupling partner scope and tolerates many functional groups.