TOXIC EQUIVALENCY FACTORS FOR DIOXIN-LIKE PCBS - REPORT ON A WHO-ECEH AND IPCS CONSULTATION, DECEMBER 1993
TOXIC EQUIVALENCY FACTORS FOR DIOXIN-LIKE PCBS - REPORT ON A WHO-ECEH AND IPCS CONSULTATION, DECEMBER 1993
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DOI：
10.1016/0045-6535(94)90324-7
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发表时间：
1994-03-01
期刊：
影响因子：
8.8
通讯作者：
YRJANHEIKKI, E
中科院分区：
文献类型：
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作者：
AHLBORG, UG;BECKING, GC;YRJANHEIKKI, E
世卫组织-欧洲环境与健康中心（世卫组织-欧洲环境与健康中心）和国际化学品安全方案（化学品安全方案）发起了一个项目，以建立一个数据库，其中载有与确定毒性当量系数有关的信息，并根据现有信息，评估多氯二苯并对二恶英、多氯二苯并呋喃和二恶英类多氯联苯的相对毒性，并得出共识毒性当量系数。收集并分析了二恶英类多氯联苯相对于一些终点的相对毒性的现有数据。在荷兰Bilthoven的世卫组织-欧洲环境与健康中心举行了一次磋商，会上讨论了现有数据，以得出二恶英类多氯联苯的毒性当量系数。对3种非邻位、8种单邻位和2种二邻位取代的多氯联苯推荐了TEF。协商会议建议扩大该项目的范围，以包括多氯二苯并对二恶英和多氯二苯并呋喃以及其他二恶英类卤化环境污染物。还有人建议，应探讨是否有可能为身体负荷和生态毒理学建立单独的毒性当量因子。
The WHO-European Centre for Environment and Health (WHO-ECEH) and the International Programme on Chemical Safety (IPCS), have initiated a project to create a data base containing information relevant to the setting of Toxic Equivalency Factors (TEFs), and, based on the available information, to assess the relative Potencies and to derive consensus TEFs for PCDDs, PCDFs and dioxin-like PCBs. Available data on the relative toxicities of dioxin-like PCBs with respect to a number of endpoints were collected and analyzed. A consultation was held at the WHO-European Centre for Environment and Health in Bilthoven, the Netherlands, at which the available data were discussed to derive TEFs for dioxin-like PCBs. TEFs were recommended for 3 non-ortho-, 8 mono-ortho- and 2 di-ortho-substituted PCBs. The consultation recommended that the project should be extended to include PCDDs and PCDFs and other dioxin-like halogenated environmental pollutants. It was also recommended that the possibilities of separate TEFs for body burdens and ecotoxicology should be explored.