Recent Advances in Synthetic Methods for Radioiodination
Recent Advances in Synthetic Methods for Radioiodination
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DOI：
10.1021/acs.joc.0c00644
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发表时间：
2020-07-02
影响因子：
3.6
通讯作者：
Cailly, Thomas
中科院分区：
文献类型：
--
作者：
Dubost, Emmanuelle;McErlain, Holly;Cailly, Thomas
具有碘的放射性同位素的有机化合物广泛用于生物研究、诊断成像和放射治疗。早期报道的用于掺入放射性碘的合成方法通常涉及高温反应或强氧化条件。为了克服这些局限性并科普对新型放射性碘标记探针的需求，放射性碘标记的新合成方法学的开发出现了激增。本概要介绍了最近开发的关键转型。
Organic compounds bearing radioisotopes of iodine are widely used for biological research, diagnostic imaging, and radiotherapy. Early reported synthetic methods for the incorporation of radioiodine have generally involved high temperature reactions or strongly oxidizing conditions. To overcome these limitations and to cope with the demand for novel radioiodinated probes, there has been a surge in the development of new synthetic methodology for radioiodination. This synopsis describes the key transformations developed recently.