Is bile acid a determinant of the gut microbiota on a high-fat diet?
Is bile acid a determinant of the gut microbiota on a high-fat diet?
复制标题
DOI：
10.4161/gmic.21216
复制
发表时间：
2012-07
期刊：
影响因子：
12.2
通讯作者：
A. Yokota;S. Fukiya;K. Islam;Tadasuke Ooka;Yoshitoshi Ogura;Tetsuya Hayashi;Masahito Hagio;S. Ishizuka-S.
中科院分区：
文献类型：
--
作者：
A. Yokota;S. Fukiya;K. Islam;Tadasuke Ooka;Yoshitoshi Ogura;Tetsuya Hayashi;Masahito Hagio;S. Ishizuka-S.
最近，我们发现胆汁酸是胆汁的主要成分，是调节大鼠盲肠微生物群组成的宿主因子。由于胆汁分泌在高脂肪饮食中增加，并且胆汁酸通常具有很强的抗菌活性，因此我们推测胆汁酸将是肠道微生物群对高脂肪饮食做出反应的决定因素。在大鼠盲肠微生物群中观察到的由胆酸（人类胆汁中最丰富的胆汁酸）给药引发的变化与在喂食高脂饮食的动物中发现的变化相似。在这里，我们讨论了这一假设的基本原理，通过评估报告的饮食诱导的肠道微生物群的改变的基础上，假设胆汁酸作为一个潜在的决定因素。确定决定肠道微生物群的宿主因素极大地有助于理解肠道微生物群变化与疾病发展之间的因果关系，这仍有待阐明。
Recently, we discovered that bile acid, a main component of bile, is a host factor that regulates the composition of the cecal microbiota in rats. Because bile secretion increases on a high-fat diet and bile acids generally have strong antimicrobial activity, we speculated that bile acids would be a determinant of the gut microbiota in response to a high-fat diet. The observed changes in the rat cecal microbiota triggered by cholic acid (the most abundant bile acid in human biliary bile) administration resemble those found in animals fed high-fat diets. Here, we discuss the rationale for this hypothesis by evaluating reported diet-induced gut microbiota alterations based on the postulate that bile acids worked as an underlying determinant. The identification of host factors determining the gut microbiota greatly contributes to understanding the causal relationships between changes in the gut microbiota and disease development, which remain to be elucidated.