Host signal transduction and protein kinases implicated in Legionella infection.
Host signal transduction and protein kinases implicated in Legionella infection.
复制标题
军团菌感染涉及宿主信号转导和蛋白激酶。
DOI：
10.1007/82_2013_342
复制
发表时间：
2013
影响因子：
--
通讯作者：
Isberg,RalphR
中科院分区：
文献类型：
--
作者：
Hempstead,AndrewD;Isberg,RalphR
Modulation of the phosphorylation status of proteins by both kinases and phosphatases plays an important role in cellular signal transduction. Challenge of host cells byLegionella pneumophilamanipulates the phosphorylation state of multiple host factors. These changes play roles in bacterial uptake, vacuole modification, cellular survival, and the immune response. In addition to modification by host cell kinases in response to the bacterium,L. pneumophilatranslocates bacterial kinases into the host cell that may contribute to further signaling modifications. Proper regulation of host cell signaling byL. pneumophilais necessary for its ability to replicate intracellulary, while avoiding host defenses.
