PHAGE-HOST RELATIONSHIPS IN NONTOXIGENIC AND TOXIGENIC DIPHTHERIA-BACILLI
PHAGE-HOST RELATIONSHIPS IN NONTOXIGENIC AND TOXIGENIC DIPHTHERIA-BACILLI
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DOI：
10.1128/jb.67.2.220-232.1954
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发表时间：
1954-01-01
影响因子：
3.2
通讯作者：
PAPPENHEIMER, AM
中科院分区：
文献类型：
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作者：
BARKSDALE, WL;PAPPENHEIMER, AM
C.从Freeman获得的白喉噬菌体含有裂解性噬菌体和其温和突变体[β]。噬菌体B几乎完全裂解指示菌株C4（C444）和C7（C770）。噬菌体[β]在引起部分裂解的同时，是负责将指示菌株转化为其溶源性、产纤维素衍生物C4（[β]）和C7（[β]）的活性剂，其对噬菌体B的裂解具有抗性。在所有其他方面，B和[β] β的行为是相同的，即，爆发大小和潜伏期对指示菌株、吸附速率、稳定性和热灭活速率的影响。C4（[beta]）和C7（[beta]）菌株中的[beta] -噬菌体发育可能由u. v.光照射。经典的PW 8菌株也是溶源性的，可能是辐射诱导的。P.W. 8的宿主范围不同于B和[beta] β。测定了C_4到C_4（[β]_1）的转化率。在不同的β 1噬菌体多样性下。
C. diphtheriae bacteriophage obtained from Freeman contained a lytic phage, , and its temperate mutant [beta]. Phage B causes almost complete lysis of the indicator strains C4(C444) and C7(C770). Phage[beta], while causing partial lysis, is the active agent responsible for converting the indicator strains to their lysogenic, toxigenic derivatives, C4 ([beta]) and C7 ([beta]), which are resistant to lysis by phage B. In all other respects the behavior of B and [beta] phages is identical, i.e., effect of burst size and latent period on the indicator strains, rate of adsorption, stability, and rate of heat inactivation. [beta] -phage development in the C4([beta]) and C7([beta]) strains may be induced by u.-v. light irradiation. The classic P.W. 8 strain is also lysogenic and may be induced by irradiation. The phage liberated by P.W. 8 differs in its host range from B and [beta] phages. The conversion rate of C4 to C4 ([beta]1) has been detd. at different [beta]1, phage multiplicities.