Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?
Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?
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DOI：
10.1038/ncb1208-1379
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发表时间：
2008-12-01
影响因子：
21.3
通讯作者：
Casal, Jose
中科院分区：
文献类型：
--
作者：
Lawrence, Peter A.;Struhl, Gary;Casal, Jose
大多数，也许所有上皮片中的细胞都在片面上极化。这种类型的极性被称为平面细胞极性(PCP)，可表达在纤毛和立体纤毛的取向、定向突起(如毛发)、细胞分裂平面、定向细胞运动以及可能的轴突延伸的取向(1，2)。目前研究的另一个热门领域是生长：有人试图找到固定器官形状和大小的系统。虽然极性和生长都受到形态梯度的全面控制(3)，但这种控制的机制几乎完全不清楚。在这里，我们讨论“陡度假说”的最新证据，该假说将动物发育的这两个明显互不相关的特征联系在一起。
Most, perhaps all cells in epithelial sheets are polarized in the plane of the sheet. This type of polarity, referred to as planar cell polarity (PCP), can be expressed in the orientation of cilia and stereocilia, in oriented outgrowths such as hairs, in the plane of cell division, in directed cell movement and possibly in the orientation of axon extension(1,2). Another popular area in current research is growth: there is an attempt to find systems that fix the shape and size of organs. Although both polarity and growth are subject to overall control by morphogen gradients(3), the mechanisms of this control are almost completely unknown. Here we discuss recent evidence for a 'steepness hypothesis' that links these two apparently disconnected features of animal development.