Spike doublets in neurons of the lateral amygdala: Mechanisms and contribution to rhythmic activity
Spike doublets in neurons of the lateral amygdala: Mechanisms and contribution to rhythmic activity
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DOI：
10.1097/00001756-200006050-00022
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发表时间：
2000-06-05
期刊：
影响因子：
1.7
通讯作者：
Pape, HC
中科院分区：
文献类型：
--
作者：
Driesang, RB;Pape, HC
外侧杏仁核中的大多数投射神经元在θ频率范围内产生振荡尖峰放电，这主要是由于固有的膜特性。在这里，我们报告的尖峰双峰发生在约70%的这些细胞。尖峰双峰由一个快速的初始和第二个较慢的组件，这是介导的钠和钙依赖性机制，分别。随着去极化程度的增加，快速动作电位逐渐过渡，快速动作电位和锋电位双峰有规律的交替，规则的锋电位双峰和高阈值振荡。快速傅里叶变换证明了尖峰倍增器在3 Hz左右的节律性，双峰内频率为25 - 80 Hz。因此，棘波双峰可能有助于投射细胞膜电位模式的整体节律性，并支持突触输入信号的整合。NeuroReport 11：1703 - 1708（C）2000 Lippincott威廉姆斯和威尔金斯。
A majority of projection neurons in the lateral amygdala generate oscillatory spike firing in the theta-frequency range, largely due to intrinsic membrane properties. Here we report on the occurrence of spike doublets in about 70% of these cells. Spike doublets consisted of a fast initial and a second slower component, which were mediated by sodium- and calcium-dependent mechanisms, respectively. With increased level of depolarization, there was a gradual transition of fast action potentials, regular alternation of fast action potentials and spike doublets, regular spike doublets, and high-threshold oscillations. Fast Fourier transforms demonstrated the rhythmic nature of spike doublers at around 3 Hz with an intra-doublet frequency of 25-80 Hz. Spike doublets may thus contribute to the overall rhythmicity in the membrane potential patterns of projection cells and support the integration of synaptic input signals. NeuroReport 11:1703-1708 (C) 2000 Lippincott Williams & Wilkins.