Function of PPR proteins in plastid gene expression
Function of PPR proteins in plastid gene expression
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DOI：
10.4161/rna.25207
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发表时间：
2013-05
期刊：
影响因子：
4.1
通讯作者：
T. Shikanai;Sota Fujii
中科院分区：
文献类型：
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作者：
T. Shikanai;Sota Fujii
PPR蛋白在开花植物中形成一个庞大的家族，并参与质体和线粒体中的RNA成熟。这些蛋白质是序列特异性RNA结合蛋白，其募集RNA加工的机器。本文综述了不同RNA成熟的功能机制和RNA序列识别机制的研究进展。我们进一步关注两个主题。RNA编辑是细胞器中RNA成熟的一个神秘过程，其中PLS亚家族的成员有助于靶位点识别。作为第一个主题，我们推测为什么PLS亚家族被RNA编辑机制选择。其次，我们讨论了质体基因表达的调节如何有助于高效光合作用。尽管PPR蛋白的分子功能已被广泛研究，但有关这些蛋白调节的生理意义的信息仍然非常有限。
PPR proteins form a huge family in flowering plants and are involved in RNA maturation in plastids and mitochondria. These proteins are sequence-specific RNA-binding proteins that recruit the machinery of RNA processing. We summarize progress in the research on the functional mechanisms of divergent RNA maturation and on the mechanism by which RNA sequences are recognized. We further focus on two topics. RNA editing is an enigmatic process of RNA maturation in organelles, in which members of the PLS subfamily contribute to target site recognition. As the first topic, we speculate on why the PLS subfamily was selected by the RNA editing machinery. Second, we discuss how the regulation of plastid gene expression contributes to efficient photosynthesis. Although the molecular functions of PPR proteins have been studied extensively, information on the physiological significance of regulation by these proteins remains very limited.