NOREPINEPHRINE TURNOVER IN OBESE (OB OB) MICE - EFFECTS OF AGE, FASTING, AND ACUTE COLD
NOREPINEPHRINE TURNOVER IN OBESE (OB OB) MICE - EFFECTS OF AGE, FASTING, AND ACUTE COLD
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DOI：
10.1152/ajpendo.1983.244.6.e567
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发表时间：
1983-01-01
影响因子：
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通讯作者：
ROMSOS, DR
中科院分区：
文献类型：
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作者：
KNEHANS, AW;ROMSOS, DR
本文探讨了8周龄肥胖（ob/ob）小鼠棕色脂肪组织（BAT）中交感神经系统（SNS）活性降低与该年龄肥胖的可能性。去甲肾上腺素（NE）营业额，SNS活动的估计，在BAT和其他器官的2周龄肥胖前期ob/ob小鼠，并在4和8周龄。肥胖前期ob/ob小鼠的BAT中NE周转率比同窝瘦小鼠慢36%，并且在4周龄（-66%）和8周龄（56%）时BAT中保持缓慢。在心脏中，肥胖前期ob/ob小鼠的NE转换速率比同窝瘦鼠慢48%，但在4周龄（-21%）和8周龄（-16%）时差异减小。肥胖小鼠的白色脂肪组织、肝脏和胰腺的NE周转率通常与瘦小鼠的这些器官的NE周转率相当。禁食（24小时）和急性冷暴露（14度）的影响。C处理8 h）。一般来说，禁食降低和冷暴露升高NE周转同样在肥胖和瘦小鼠。在23 ℃下饲养的Ob/ob小鼠25.degree. C在肥胖症发作之前在他们的BAT中表现出低SNS活性，即使他们的BAT中的SNS活性正常地响应于急性冷应激。这种低SNS活动可能有助于他们随后的高效率的能量保留。
The possibility that low sympathetic nervous system (SNS) acivity in brown adipose tissue (BAT) of 8-wk-old obese (ob/ob) mice results from their gross obesity at that age was investigated. Norepinephrine (NE) turnover, an estimator of SNS activity, was measured in BAT and other organs of 2-wk-old preobese ob/ob mice, and at 4 and 8 wk of age. Rates of NE turnover were 36% slower in BAT of preobese ob/ob mice than in lean littermates and remained slow in their BAT at 4 (-66%) and 8 (56%) wk of age. In the heart, rates of NE turnover were 48% slower in preobese ob/ob mice than in lean littermates, but the difference diminished at 4 (-21%) and 8 (-16%) wk of age. Rates of NE turnover in white adipose tissue, liver, and pancreas of obese mice were generally comparable with rates in these organs of lean mice. Effects of fasting (24 h) and acute cold exposure (14.degree. C for 8 h) were also examined. In general, fasting lowered and cold exposure elevated NE turnover equally in obese and lean mice. Ob/ob mice housed at 23.degree.-25.degree. C exhibit low SNS activity in their BAT prior to the onset of gross obesity, even though SNS activity in their BAT responds normally to an acute cold stress. This low SNS activity probably contributes to their subsequent high efficiency of energy retention.