A concise synthesis of the pentacyclic framework of cortistatins
A concise synthesis of the pentacyclic framework of cortistatins
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DOI：
10.1021/ol8012099
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发表时间：
2008-08-21
期刊：
影响因子：
5.2
通讯作者：
Hirama, Masahiro
中科院分区：
文献类型：
--
作者：
Yamashita, Shuji;Iso, Kentaro;Hirama, Masahiro
开发了一种高效合成皮质抑素五环骨架的方法。关键策略包括通过Knoevenagel反应组装A环和CD环片段、通过电环化轻松形成吡喃环以及通过自由基加成到α，β-不饱和酮上构建七元B环。
An efficient synthesis of the pentacyclic framework of cortistatins has been developed. The key strategy comprises assembly of the A- and the CD-ring fragments by Knoevenagel reaction, facile formation of the pyran ring via electrocyclization, and construction of the seven-membered B-ring by radical addition to an alpha,beta-unsaturated ketone.