EFFECTS OF HUNGER ON RESPONSES OF NEURONS IN LATERAL HYPOTHALAMUS TO SIGHT AND TASTE OF FOOD
EFFECTS OF HUNGER ON RESPONSES OF NEURONS IN LATERAL HYPOTHALAMUS TO SIGHT AND TASTE OF FOOD
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DOI：
10.1016/0014-4886(76)90189-8
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发表时间：
1976-01-01
影响因子：
5.3
通讯作者：
MORA, F
中科院分区：
文献类型：
--
作者：
BURTON, MJ;ROLLS, ET;MORA, F
记录是从猴子外侧下丘脑和无名质的单个神经元中进行的，这些神经元先前在饥饿的猴子品尝食物和/或看着食物时会增加或减少其放电率。这些神经元对食物的反应性随着饱腹感的增加而降低。当通过猴子是否拒绝葡萄糖来衡量饱腹感时，神经元对葡萄糖的味道和/或视觉没有反应。这些细胞的自发放电率不受从饥饿到饱腹的过渡的影响。下丘脑细胞对食物反应的这种调节是它们特有的，因为在苍白球的细胞中没有看到这种调节，苍白球的细胞对吞咽和嘴部运动有反应，或者在视觉颞下皮层的细胞中没有看到这种调节，当猴子看着含葡萄糖的注射器时，视觉颞下皮层有反应。这些下丘脑细胞可能参与动物看到或品尝食物时发生的自主，内分泌和/或进食反应。
Recordings were made from single neurons in the monkey lateral hypothalamus and substantia innominata which had previously responded with an increase or decrease of their firing rates when the hungry monkey tasted food, and/or when he looked at food. The responsiveness of these neurons to food decreased over the course of a meal of glucose as satiety increased. When satiety, measured by whether the monkey rejected the glucose, was complete, there was no response of the neurons to the taste and/or to the sight of glucose. The spontaneous firing rates of these cells were not affected by the transitions from hunger to satiety. This modulation of responsiveness to food of hypothalamic cells was specific to them in that it was not seen in cells in the globus pallidus which responded in relation to swallowing and mouth movements, or in cells in the visual inferotemporal cortex which responded when the monkey looked at the glucose-containing syringe. These hypothalamic cells could be involved in the autonomic, endocrine, and/or feeding responses which occur when an animal sees or tastes food.